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Nacc2 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing [ Mus musculus (house mouse) ]

Gene ID: 67991, updated on 11-Apr-2024

Summary

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Official Symbol
Nacc2provided by MGI
Official Full Name
nucleus accumbens associated 2, BEN and BTB (POZ) domain containingprovided by MGI
Primary source
MGI:MGI:1915241
See related
Ensembl:ENSMUSG00000026932 AllianceGenome:MGI:1915241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btbd14a; 0610020I02Rik; C030048H19Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Predicted to be located in chromatin; mitochondrion; and nucleolus. Is expressed in several structures, including brain; limb; renal calyx; submandibular gland primordium; and tooth. Orthologous to human NACC2 (NACC family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 26.3), bladder adult (RPKM 17.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 18.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25945547..26012823, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26055535..26122811, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene ubiquitin associated domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3363 Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene VISTA enhancer mm561 Neighboring gene predicted gene, 54107 Neighboring gene transmembrane protein 250

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Xuan C, et al. Oncogene, 2013 Aug 8. PMID 22926524
  2. A protein interaction network for pluripotency of embryonic stem cells. Wang J, et al. Nature, 2006 Nov 16. PMID 17093407
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleus accumbens-associated protein 2
Names
BTB (POZ) domain containing 14A
BTB/POZ domain-containing protein 14A
NAC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037098.1 → NP_001032175.1  nucleus accumbens-associated protein 2

    See identical proteins and their annotated locations for NP_001032175.1

    Status: VALIDATED

    Source sequence(s)
    AK147293, AK147310, BE983327, CN668689
    Consensus CDS
    CCDS15796.1
    UniProtKB/Swiss-Prot
    Q3TZD3, Q8VDF8, Q9DCM7
    Related
    ENSMUSP00000109796.3, ENSMUST00000114159.9
    Conserved Domains (3) summary
    smart01025
    Location:371 → 448
    BEN; The BEN domain is found in diverse animal proteins
    cd18289
    Location:1 → 131
    BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)
    pfam02161
    Location:139 → 241
    Prog_receptor; Progesterone receptor

  2. NM_026495.3 → NP_080771.3  nucleus accumbens-associated protein 2

    See identical proteins and their annotated locations for NP_080771.3

    Status: VALIDATED

    Source sequence(s)
    AK147293, CN668689
    Consensus CDS
    CCDS15796.1
    UniProtKB/Swiss-Prot
    Q3TZD3, Q8VDF8, Q9DCM7
    Related
    ENSMUSP00000028300.6, ENSMUST00000028300.6
    Conserved Domains (3) summary
    smart01025
    Location:371 → 448
    BEN; The BEN domain is found in diverse animal proteins
    cd18289
    Location:1 → 131
    BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)
    pfam02161
    Location:139 → 241
    Prog_receptor; Progesterone receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25945547..26012823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498260.1 → XP_006498323.1  nucleus accumbens-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006498323.1

    Conserved Domains (3) summary
    smart01025
    Location:344 → 421
    BEN; The BEN domain is found in diverse animal proteins
    cl38908
    Location:1 → 104
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam02161
    Location:112 → 214
    Prog_receptor; Progesterone receptor

  2. XM_006498259.1 → XP_006498322.1  nucleus accumbens-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006498322.1

    Conserved Domains (3) summary
    smart01025
    Location:344 → 421
    BEN; The BEN domain is found in diverse animal proteins
    cl38908
    Location:1 → 104
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam02161
    Location:112 → 214
    Prog_receptor; Progesterone receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCM7.1 GenPept UniProtKB/Swiss-Prot:Q9DCM7

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