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Tmx3 thioredoxin-related transmembrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 67988, updated on 11-Apr-2024

Summary

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Official Symbol
Tmx3provided by MGI
Official Full Name
thioredoxin-related transmembrane protein 3provided by MGI
Primary source
MGI:MGI:2442418
See related
Ensembl:ENSMUSG00000024614 AllianceGenome:MGI:2442418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Txndc10; mKIAA1830; 6430411B10Rik; A730024F05Rik
Summary
Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in peptidyl-cysteine oxidation. Located in cell surface. Is expressed in embryo; eye; lens epithelium; retina; and retina outer nuclear layer. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 8.1), cerebellum adult (RPKM 7.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E4; 18 59.37 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (90528336..90561391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (90510154..90543267)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45306 Neighboring gene predicted gene, 18280 Neighboring gene STARR-seq mESC enhancer starr_45307 Neighboring gene STARR-positive B cell enhancer ABC_E7622 Neighboring gene predicted gene, 25418 Neighboring gene STARR-seq mESC enhancer starr_45308 Neighboring gene STARR-seq mESC enhancer starr_45309 Neighboring gene predicted gene 45871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nt mutation causing laterality defects associated with deletion of rotatin. Chatterjee B, et al. Mamm Genome, 2007 May. PMID 17551791
  2. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. Chao R, et al. PLoS One, 2010 May 11. PMID 20485507, Free PMC Article
  3. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Holbrook LM, et al. Br J Haematol, 2010 Feb. PMID 19995400
  4. Deletion of Lrp4 increases the incidence of microphthalmia. Tanahashi H, et al. Biochem Biophys Res Commun, 2018 Nov 30. PMID 30352686
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase TMX3
Names
thioredoxin domain containing 10
thioredoxin domain-containing protein 10
NP_938037.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198295.3 → NP_938037.2  protein disulfide-isomerase TMX3 precursor

    See identical proteins and their annotated locations for NP_938037.2

    Status: VALIDATED

    Source sequence(s)
    AC163277
    Consensus CDS
    CCDS37879.1
    UniProtKB/Swiss-Prot
    Q3US84, Q6PGA1, Q6ZPH5, Q8BXZ1, Q8BZB8
    Related
    ENSMUSP00000025515.7, ENSMUST00000025515.7
    Conserved Domains (3) summary
    cd03000
    Location:30 → 133
    PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...
    pfam13848
    Location:163 → 340
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:260 → 343
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    90528336..90561391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXZ1.2 GenPept UniProtKB/Swiss-Prot:Q8BXZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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