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Ccny cyclin Y [ Mus musculus (house mouse) ]

Gene ID: 67974, updated on 5-Mar-2024

Summary

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Official Symbol
Ccnyprovided by MGI
Official Full Name
cyclin Yprovided by MGI
Primary source
MGI:MGI:1915224
See related
Ensembl:ENSMUSG00000024286 AllianceGenome:MGI:1915224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and cell division. Predicted to be located in nucleus. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; mammary gland; and spleen. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.9), ovary adult (RPKM 20.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccny in Genome Data Viewer
Location:
18 A1; 18 4.91 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9312304..9450188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9312304..9450154, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1632 Neighboring gene frizzled class receptor 8 Neighboring gene STARR-seq mESC enhancer starr_43772 Neighboring gene STARR-seq mESC enhancer starr_43773 Neighboring gene STARR-seq mESC enhancer starr_43774 Neighboring gene gap junction protein, delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E7573 Neighboring gene STARR-seq mESC enhancer starr_43776 Neighboring gene predicted gene, 35458 Neighboring gene family with sequence similarity 76, member A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Seo J, et al. Mol Psychiatry, 2023 Mar. PMID 36434054, Free PMC Article
  2. The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis. Molinas A, et al. Cells, 2021 Sep 6. PMID 34571979, Free PMC Article
  3. Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy. Hwang H, et al. Pharmacol Res, 2020 Oct. PMID 32739426
  4. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. An W, et al. PLoS One, 2015. PMID 26161966, Free PMC Article
  5. [Phosphorus-calcium metabolism in children under long-term anticonvulsant therapy]. Lluch Fernández MD, et al. An Esp Pediatr, 1991 Aug. PMID 1952457

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
    Title: Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
  2. Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
    Title: Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
  3. Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
    Title: Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.
  4. these results provide a new link between CCNY and lipid metabolism in mice.
    Title: Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
  5. CDK16 isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
    Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-Y
Names
cyclin fold protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026484.4 → NP_080760.2  cyclin-Y

    See identical proteins and their annotated locations for NP_080760.2

    Status: VALIDATED

    Source sequence(s)
    AC108777, AK014201, AK014507, AK028696, AW048376
    Consensus CDS
    CCDS29050.1
    UniProtKB/Swiss-Prot
    Q8BGU5, Q8CI87, Q9CYN5
    Related
    ENSMUSP00000050001.5, ENSMUST00000053917.6
    Conserved Domains (1) summary
    cd20540
    Location:166 → 262
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    9312304..9450188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250583.2 → XP_030106443.1  cyclin-Y isoform X2

    Conserved Domains (1) summary
    pfam00134
    Location:101 → 223
    Cyclin_N; Cyclin, N-terminal domain

  2. XM_030250584.2 → XP_030106444.1  cyclin-Y isoform X4

    Conserved Domains (1) summary
    cd20540
    Location:27 → 123
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

  3. XM_036161266.1 → XP_036017159.1  cyclin-Y isoform X4

    Conserved Domains (1) summary
    cd20540
    Location:27 → 123
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

  4. XM_030250582.1 → XP_030106442.1  cyclin-Y isoform X1

    Conserved Domains (1) summary
    pfam00134
    Location:89 → 211
    Cyclin_N; Cyclin, N-terminal domain

  5. XM_036161265.1 → XP_036017158.1  cyclin-Y isoform X3

    Conserved Domains (1) summary
    cl40454
    Location:166 → 193
    CYCLIN_SF; Cyclin box fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGU5.1 GenPept UniProtKB/Swiss-Prot:Q8BGU5

Gene LinkOut

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