Tppp3 tubulin polymerization-promoting protein family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tppp3provided by MGI
Official Full Name: tubulin polymerization-promoting protein family member 3provided by MGI
Primary source: MGI:MGI:1915221
See related: Ensembl:ENSMUSG00000014846 AllianceGenome:MGI:1915221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CGI-38; mmCGM8; Ceacam9; 2700055K07Rik
Summary: Predicted to enable tubulin binding activity. Involved in embryo implantation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to colocalize with microtubule; microtubule bundle; and perinuclear region of cytoplasm. Is expressed in several structures, including limb; lung; musculature; nervous system; and sensory organ. Orthologous to human TPPP3 (tubulin polymerization promoting protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 106.8), colon adult (RPKM 48.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106194124..106198189, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105467492..105471422, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results support Tppp3(+)Pdgfra(+) cells as tendon stem cells.
Title: A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis.
Data suggest that tubulin polymerization-promoting protein family member 3 (TPPP3) plays a significant role in decidualization.
Title: Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization.
The suppression of beta-catenin in uterus under the condition of transient knockdown of TPPP3 and the co-immunoprecipitation experiment revealed that regulation of beta-catenin was mediated via TPPP3 during implantation
Title: Uterine TPPP3 plays important role in embryo implantation via modulation of β-catenin.
findings suggested that the TPPP3 gene played an important role in tumorigenesis and metastasis, and it could potentially become a novel target for cancer therapy
Title: Stable knockdown of TPPP3 by RNA interference in Lewis lung carcinoma cell inhibits tumor growth and metastasis.
onset of Tppp3 expression in joints coincides with cavitation, representing a molecular marker that can be used to indicate this stage in joint transition in joint differentiation
Title: Tubulin polymerization-promoting protein family member 3, Tppp3, is a specific marker of the differentiating tendon sheath and synovial joints.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

MARC_24063-24064:1030024087:1 (e-PCR)
- UniSTS:268839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein polymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule bundle	ISO Inferred from Sequence Orthology more info
colocalizes_with perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin polymerization-promoting protein family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026481.3 → NP_080757.1 tubulin polymerization-promoting protein family member 3

See identical proteins and their annotated locations for NP_080757.1

Status: VALIDATED

Source sequence(s)

AK160507, AW494372, BF469439

Consensus CDS

CCDS22602.1

UniProtKB/Swiss-Prot

Q3TUZ0, Q9CRB6

UniProtKB/TrEMBL

Q1JPR8

Related

ENSMUSP00000014990.7, ENSMUST00000014990.13

Conserved Domains (1) summary

pfam05517
Location:11 → 166

p25-alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106194124..106198189 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154254.1 → XP_036010147.1 tubulin polymerization-promoting protein family member 3 isoform X1

UniProtKB/Swiss-Prot

Q3TUZ0, Q9CRB6

UniProtKB/TrEMBL

Q1JPR8

Related

ENSMUSP00000135040.2, ENSMUST00000177126.8

Conserved Domains (1) summary

pfam05517
Location:11 → 166

p25-alpha