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Puf60 poly-U binding splicing factor 60 [ Mus musculus (house mouse) ]

Gene ID: 67959, updated on 16-Apr-2024

Summary

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Official Symbol
Puf60provided by MGI
Official Full Name
poly-U binding splicing factor 60provided by MGI
Primary source
MGI:MGI:1915209
See related
Ensembl:ENSMUSG00000002524 AllianceGenome:MGI:1915209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIAHBP1; 2410104I19Rik; 2810454F19Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; mRNA splice site selection; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing; apoptotic process; and mRNA processing. Predicted to be located in cell junction and nucleoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human PUF60 (poly(U) binding splicing factor 60). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 127.4), adrenal adult (RPKM 124.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75942031..75954386, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76070182..76082537, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952 Neighboring gene STARR-seq mESC enhancer starr_39038 Neighboring gene predicted gene, 48952 Neighboring gene nuclear receptor binding protein 2 Neighboring gene predicted gene, 41349

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Matsushita K, et al. Oncotarget, 2015 Mar 10. PMID 25671302, Free PMC Article
  2. Analysis of phosphorylation-dependent protein-protein interactions of histone h3. Klingberg R, et al. ACS Chem Biol, 2015 Jan 16. PMID 25330109
  3. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  4. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411
  5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(U)-binding-splicing factor PUF60
Names
60 kDa poly(U)-binding-splicing factor
fuse-binding protein-interacting repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164600.1 → NP_001158072.1  poly(U)-binding-splicing factor PUF60 isoform c

    See identical proteins and their annotated locations for NP_001158072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC116487, AK168789, AW488875
    UniProtKB/Swiss-Prot
    Q3UEB3
    Conserved Domains (1) summary
    TIGR01645
    Location:1 → 499
    half-pint; poly-U binding splicing factor, half-pint family

  2. NM_001356629.2 → NP_001343558.1  poly(U)-binding-splicing factor PUF60 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC116487
    Conserved Domains (1) summary
    TIGR01645
    Location:2 → 557
    half-pint; poly-U binding splicing factor, half-pint family

  3. NM_001378984.1 → NP_001365913.1  poly(U)-binding-splicing factor PUF60 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC116487
    Conserved Domains (1) summary
    TIGR01645
    Location:9 → 563
    half-pint; poly-U binding splicing factor, half-pint family

  4. NM_001378985.1 → NP_001365914.1  poly(U)-binding-splicing factor PUF60 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC116487
    Conserved Domains (1) summary
    TIGR01645
    Location:9 → 546
    half-pint; poly-U binding splicing factor, half-pint family

  5. NM_001378986.1 → NP_001365915.1  poly(U)-binding-splicing factor PUF60 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC116487
    Conserved Domains (1) summary
    TIGR01645
    Location:2 → 540
    half-pint; poly-U binding splicing factor, half-pint family

  6. NM_001403043.1 → NP_001389972.1  poly(U)-binding-splicing factor PUF60 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC116487

  7. NM_001403044.1 → NP_001389973.1  poly(U)-binding-splicing factor PUF60 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC116487

  8. NM_001403045.1 → NP_001389974.1  poly(U)-binding-splicing factor PUF60 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC116487

  9. NM_001403046.1 → NP_001389975.1  poly(U)-binding-splicing factor PUF60 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC116487

  10. NM_028364.3 → NP_082640.2  poly(U)-binding-splicing factor PUF60 isoform a

    See identical proteins and their annotated locations for NP_082640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC116487
    Consensus CDS
    CCDS37112.1
    UniProtKB/Swiss-Prot
    Q3TGC6, Q3UEB3, Q91VR6
    Related
    ENSMUSP00000098096.5, ENSMUST00000100527.13
    Conserved Domains (1) summary
    TIGR01645
    Location:7 → 564
    half-pint; poly-U binding splicing factor, half-pint family

  11. NM_133691.6 → NP_598452.2  poly(U)-binding-splicing factor PUF60 isoform b

    See identical proteins and their annotated locations for NP_598452.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC116487
    Consensus CDS
    CCDS37111.1
    UniProtKB/Swiss-Prot
    Q3UEB3
    Related
    ENSMUSP00000002599.10, ENSMUST00000002599.11
    Conserved Domains (1) summary
    TIGR01645
    Location:7 → 547
    half-pint; poly-U binding splicing factor, half-pint family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75942031..75954386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248718.1 → XP_030104578.1  poly(U)-binding-splicing factor PUF60 isoform X1

    Conserved Domains (1) summary
    TIGR01645
    Location:41 → 598
    half-pint; poly-U binding splicing factor, half-pint family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UEB3.2 GenPept UniProtKB/Swiss-Prot:Q3UEB3

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