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Spata6 spermatogenesis associated 6 [ Mus musculus (house mouse) ]

Gene ID: 67946, updated on 5-Mar-2024

Summary

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Official Symbol
Spata6provided by MGI
Official Full Name
spermatogenesis associated 6provided by MGI
Primary source
MGI:MGI:1915196
See related
Ensembl:ENSMUSG00000034401 AllianceGenome:MGI:1915196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRP; Hash; Mash; 1700062C23Rik
Summary
Enables myosin light chain binding activity. Involved in motile cilium assembly and spermatogenesis. Located in sperm connecting piece. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human SPATA6 (spermatogenesis associated 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 127.0) and bladder adult (RPKM 5.9) See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 51.53 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111577151..111686339)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111719951..111829142)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E2704 Neighboring gene STARR-seq mESC enhancer starr_11088 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1278 Neighboring gene STARR-positive B cell enhancer ABC_E11250 Neighboring gene STARR-seq mESC enhancer starr_11089 Neighboring gene BEN domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_11090 Neighboring gene STARR-seq mESC enhancer starr_11091 Neighboring gene STARR-seq mESC enhancer starr_11092 Neighboring gene STARR-positive B cell enhancer ABC_E4646 Neighboring gene predicted gene, 33192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:111490159-111490407 Neighboring gene STARR-seq mESC enhancer starr_11094 Neighboring gene STARR-seq mESC enhancer starr_11095 Neighboring gene predicted gene 12961 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Oh C, et al. Mol Hum Reprod, 2003 Jun. PMID 12771232
  2. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
  3. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables myosin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin light chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm connecting piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm connecting piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spermatogenesis-associated protein 6
Names
kinesin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357231.1 → NP_001344160.1  spermatogenesis-associated protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK005819, AK051574, AK153098, CK622811
    Related
    ENSMUST00000143879.8

  2. NM_026470.3 → NP_080746.3  spermatogenesis-associated protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080746.3

    Status: VALIDATED

    Source sequence(s)
    AK005819, AK051574, AK153098, CK129415
    Consensus CDS
    CCDS38836.1
    UniProtKB/Swiss-Prot
    A2AED7, Q3U6K5, Q3V104, Q8BW97, Q99MU6, Q9D9J1, Q9DAI3
    UniProtKB/TrEMBL
    A2AED8
    Related
    ENSMUSP00000036964.8, ENSMUST00000038868.14
    Conserved Domains (1) summary
    pfam14909
    Location:11 → 149
    SPATA6; Spermatogenesis-assoc protein 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    111577151..111686339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164380.1 → XP_036020273.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:1 → 41
    SPATA6; Spermatogenesis-assoc protein 6

  2. XM_006503347.5 → XP_006503410.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:1 → 41
    SPATA6; Spermatogenesis-assoc protein 6

  3. XM_006503348.5 → XP_006503411.1  spermatogenesis-associated protein 6 isoform X3

    UniProtKB/TrEMBL
    A0PJG4
    Conserved Domains (1) summary
    pfam14909
    Location:3 → 21
    SPATA6; Spermatogenesis-assoc protein 6

  4. XM_030253731.2 → XP_030109591.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:1 → 41
    SPATA6; Spermatogenesis-assoc protein 6

  5. XM_006503346.5 → XP_006503409.1  spermatogenesis-associated protein 6 isoform X1

    UniProtKB/TrEMBL
    A2AED8
    Conserved Domains (1) summary
    pfam14909
    Location:11 → 79
    SPATA6; Spermatogenesis-assoc protein 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U6K5.2 GenPept UniProtKB/Swiss-Prot:Q3U6K5

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