Zcchc3 zinc finger, CCHC domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zcchc3provided by MGI
Official Full Name: zinc finger, CCHC domain containing 3provided by MGI
Primary source: MGI:MGI:1915167
See related: Ensembl:ENSMUSG00000074682 AllianceGenome:MGI:1915167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810406K24Rik
Summary: Predicted to enable double-stranded DNA binding activity. Involved in several processes, including activation of innate immune response; cellular response to exogenous dsRNA; and positive regulation of type I interferon production. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; medulla oblongata basal plate mantle layer; skeleton; and ventral grey horn. Orthologous to human ZCCHC3 (zinc finger CCHC-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 74.98 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152253875..152256711, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152411956..152415044, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.
Title: ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.
this study shows that the Zinc-Finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors
Title: The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
Title: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234862

WI-15102 (e-PCR)
- UniSTS:35257

AI173521 (e-PCR)
- UniSTS:207590

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RIG-I signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger CCHC domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175126.5 → NP_780335.1 zinc finger CCHC domain-containing protein 3

See identical proteins and their annotated locations for NP_780335.1

Status: VALIDATED

Source sequence(s)

AL928568

Consensus CDS

CCDS16884.1

UniProtKB/Swiss-Prot

Q8BPK2

Related

ENSMUSP00000096813.4, ENSMUST00000099207.5

Conserved Domains (1) summary

COG5082
Location:330 → 383

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]