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Galntl5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 [ Mus musculus (house mouse) ]

Gene ID: 67909, updated on 9-Mar-2024

Summary

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Official Symbol
Galntl5provided by MGI
Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5provided by MGI
Primary source
MGI:MGI:1915159
See related
Ensembl:ENSMUSG00000028938 AllianceGenome:MGI:1915159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galnt15; 1700021B12Rik
Summary
Predicted to enable metal ion binding activity. Involved in spermatid development. Predicted to be located in endosome and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNTL5 (polypeptide N-acetylgalactosaminyltransferase like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 63.9) See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 12.33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25386438..25425295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25181440..25220297)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_12657 Neighboring gene STARR-seq mESC enhancer starr_12659 Neighboring gene predicted gene, 33836 Neighboring gene STARR-seq mESC enhancer starr_12661 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene lysine (K)-specific methyltransferase 2C Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility. Takasaki N, et al. Proc Natl Acad Sci U S A, 2014 Jan 21. PMID 24398516, Free PMC Article
  2. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mutated GALNTL5 has a role in male infertility with impairment of sperm motility
    Title: A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
galNAc-T15
polypeptide GalNAc transferase 15
polypeptide N-acetylgalactosaminyltransferase-like 5
pp-GaNTase 15
protein-UDP acetylgalactosaminyltransferase 15
putative polypeptide N-acetylgalactosaminyltransferase-like protein 5
NP_080725.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026449.3 → NP_080725.2  inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

    See identical proteins and their annotated locations for NP_080725.2

    Status: VALIDATED

    Source sequence(s)
    AK005605, AK016415
    Consensus CDS
    CCDS19132.1
    UniProtKB/Swiss-Prot
    A6H655, Q810S4, Q9CW06, Q9D4M9
    UniProtKB/TrEMBL
    D3Z533
    Related
    ENSMUSP00000030778.3, ENSMUST00000030778.9
    Conserved Domains (2) summary
    cd02510
    Location:118 → 414
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam10111
    Location:118 → 380
    Glyco_tranf_2_2; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    25386438..25425295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_389751.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4M9.2 GenPept UniProtKB/Swiss-Prot:Q9D4M9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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