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Sumf2 sulfatase modifying factor 2 [ Mus musculus (house mouse) ]

Gene ID: 67902, updated on 3-Apr-2024

Summary

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Official Symbol
Sumf2provided by MGI
Official Full Name
sulfatase modifying factor 2provided by MGI
Primary source
MGI:MGI:1915152
See related
Ensembl:ENSMUSG00000025538 AllianceGenome:MGI:1915152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610040F05Rik
Summary
Enables identical protein binding activity. Located in endoplasmic reticulum. Orthologous to human SUMF2 (sulfatase modifying factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 11.6), ovary adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sumf2 in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129875807..129892275)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129846990..129863951)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene phosphorylase kinase gamma 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
  2. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive C-alpha-formylglycine-generating enzyme 2
Names
C-alpha-formylglycine-generating enzyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417670.1 → NP_001404599.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC242408

  2. NM_001417671.1 → NP_001404600.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC242408

  3. NM_001417672.1 → NP_001404601.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC242408

  4. NM_026445.3 → NP_080721.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080721.1

    Status: VALIDATED

    Source sequence(s)
    AC242408
    Consensus CDS
    CCDS19700.1
    UniProtKB/Swiss-Prot
    Q3TZL1, Q3UUL0, Q8BPG6, Q9CZ47
    UniProtKB/TrEMBL
    Q3TM08
    Related
    ENSMUSP00000126036.2, ENSMUST00000171300.8
    Conserved Domains (2) summary
    COG1262
    Location:36 → 302
    YfmG; Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones]
    pfam03781
    Location:36 → 298
    FGE-sulfatase; Sulfatase-modifying factor enzyme 1

RNA

  1. NR_184559.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC242408

  2. NR_184560.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC242408
    Related
    ENSMUST00000137357.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129875807..129892275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165445.1 → XP_036021338.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform X1

    Conserved Domains (1) summary
    pfam03781
    Location:36 → 233
    FGE-sulfatase; Sulfatase-modifying factor enzyme 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPG6.2 GenPept UniProtKB/Swiss-Prot:Q8BPG6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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