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Saraf store-operated calcium entry-associated regulatory factor [ Mus musculus (house mouse) ]

Gene ID: 67887, updated on 21-Apr-2024

Summary

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Official Symbol
Sarafprovided by MGI
Official Full Name
store-operated calcium entry-associated regulatory factorprovided by MGI
Primary source
MGI:MGI:1915137
See related
Ensembl:ENSMUSG00000031532 AllianceGenome:MGI:1915137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem66; 1810045K07Rik
Summary
Predicted to be involved in regulation of store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in nervous system; nose; and tooth. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 156.6), ovary adult (RPKM 97.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 20.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34621733..34638001)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34154579..34170847)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene predicted gene, 39158 Neighboring gene leptin receptor overlapping transcript-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35217440-35217740 Neighboring gene STARR-positive B cell enhancer ABC_E10495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35226466-35226653 Neighboring gene microRNA 6395 Neighboring gene predicted gene, 33638 Neighboring gene STARR-positive B cell enhancer ABC_E4999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35279146-35279346 Neighboring gene predicted gene 29243

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models. Wang YM, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Sep 1. PMID 34231388
  2. Saraf-dependent activation of mTORC1 regulates cardiac growth. Sanlialp A, et al. J Mol Cell Cardiol, 2020 Apr. PMID 32173353
  3. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Lodder EM, et al. Circ Cardiovasc Genet, 2014 Dec. PMID 25217174
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models.
    Title: Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models.
  2. Saraf-dependent activation of mTORC1 regulates cardiac growth.
    Title: Saraf-dependent activation of mTORC1 regulates cardiac growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
store-operated calcium entry-associated regulatory factor
Names
SOCE-associated regulatory factor
transmembrane protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026432.4 → NP_080708.4  store-operated calcium entry-associated regulatory factor precursor

    Status: VALIDATED

    Source sequence(s)
    AI841528, AK007787, BY135425
    Consensus CDS
    CCDS22240.1
    UniProtKB/Swiss-Prot
    Q8C2F1, Q8C6G7, Q8N9S4, Q8R233, Q8R3Q0, Q9D8R1
    UniProtKB/TrEMBL
    A0A0R4J0D1
    Related
    ENSMUSP00000033933.7, ENSMUST00000033933.8
    Conserved Domains (1) summary
    pfam06682
    Location:25 → 334
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34621733..34638001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3Q0.2 GenPept UniProtKB/Swiss-Prot:Q8R3Q0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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