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Uxs1 UDP-glucuronate decarboxylase 1 [ Mus musculus (house mouse) ]

Gene ID: 67883, updated on 21-Apr-2024

Summary

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Official Symbol
Uxs1provided by MGI
Official Full Name
UDP-glucuronate decarboxylase 1provided by MGI
Primary source
MGI:MGI:1915133
See related
Ensembl:ENSMUSG00000057363 AllianceGenome:MGI:1915133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600025I13Rik
Summary
Predicted to enable NAD+ binding activity; UDP-glucuronate decarboxylase activity; and protein homodimerization activity. Located in mitochondrion. Is expressed in forelimb and hindlimb. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.7), placenta adult (RPKM 8.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 23.46 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (43786121..43866999, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (43746961..43827839, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30634 Neighboring gene ECRG4 augurin precursor Neighboring gene STARR-positive B cell enhancer mm9_chr1:43834650-43834950 Neighboring gene STARR-positive B cell enhancer mm9_chr1:43835251-43835552 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene ADP-ribosylation factor 1 pseudogene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid. Eixelsberger T, et al. J Biol Chem, 2012 Sep 7. PMID 22810237, Free PMC Article
  2. Locus of the gene 'fidget' in the house mouse. WALLACE ME. Nature, 1950 Sep 2. PMID 14775691
  3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. Moriarity JL, et al. J Biol Chem, 2002 May 10. PMID 11877387
  4. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables UDP-glucuronate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucuronate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-D-xylose biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
UDP-glucuronic acid decarboxylase 1
Names
UGD
UXS-1
NP_001355216.1
NP_001355217.1
NP_001355218.1
NP_080706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368287.1 → NP_001355216.1  UDP-glucuronic acid decarboxylase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159092

  2. NM_001368288.1 → NP_001355217.1  UDP-glucuronic acid decarboxylase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AC159092
    Conserved Domains (2) summary
    cd05230
    Location:50 → 353
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:1 → 39
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  3. NM_001368289.1 → NP_001355218.1  UDP-glucuronic acid decarboxylase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC159092
    Conserved Domains (2) summary
    cd05230
    Location:50 → 353
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:1 → 39
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  4. NM_026430.4 → NP_080706.1  UDP-glucuronic acid decarboxylase 1 isoform 2

    See identical proteins and their annotated locations for NP_080706.1

    Status: VALIDATED

    Source sequence(s)
    AC159092
    Consensus CDS
    CCDS35551.1
    UniProtKB/Swiss-Prot
    Q3U854, Q91XL3
    Related
    ENSMUSP00000119939.2, ENSMUST00000126008.8
    Conserved Domains (2) summary
    cd05230
    Location:89 → 392
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:4 → 78
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

RNA

  1. NR_160749.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159092, AK005536

  2. NR_160750.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159092

  3. NR_160751.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159092

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    43786121..43866999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XL3.1 GenPept UniProtKB/Swiss-Prot:Q91XL3

Gene LinkOut

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