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Mdp1 magnesium-dependent phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 67881, updated on 5-Mar-2024

Summary

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Official Symbol
Mdp1provided by MGI
Official Full Name
magnesium-dependent phosphatase 1provided by MGI
Primary source
MGI:MGI:1915131
See related
Ensembl:ENSMUSG00000002329 AllianceGenome:MGI:1915131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810034K20Rik
Summary
Predicted to enable acid phosphatase activity. Predicted to be involved in fructosamine metabolic process. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human MDP1 (magnesium dependent phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.3), large intestine adult (RPKM 18.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55895346..55897908, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55657889..55660451, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 8 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Peisach E, et al. Biochemistry, 2004 Oct 12. PMID 15461449
  2. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Selengut JD, et al. Biochemistry, 2000 Jul 18. PMID 10889041
  3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  4. MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Selengut JD. Biochemistry, 2001 Oct 23. PMID 11601995
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X ray crystallography of MDP-1
    Title: X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fructosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
magnesium-dependent phosphatase 1
Names
MDP-1
NP_075886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023397.5 → NP_075886.1  magnesium-dependent phosphatase 1

    See identical proteins and their annotated locations for NP_075886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AI846874, AK007319, BC046613
    Consensus CDS
    CCDS27123.1
    UniProtKB/Swiss-Prot
    Q9D967
    Related
    ENSMUSP00000002400.7, ENSMUST00000002400.7
    Conserved Domains (1) summary
    pfam12689
    Location:3 → 160
    Acid_PPase; Acid Phosphatase

RNA

  1. NR_028316.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron that results in a frameshift, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI846874, AK007694, BC046613
    Related
    ENSMUST00000226659.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55895346..55897908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D967.1 GenPept UniProtKB/Swiss-Prot:Q9D967

Gene LinkOut

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