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Tmem33 transmembrane protein 33 [ Mus musculus (house mouse) ]

Gene ID: 67878, updated on 30-Apr-2024

Summary

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Official Symbol
Tmem33provided by MGI
Official Full Name
transmembrane protein 33provided by MGI
Primary source
MGI:MGI:1915128
See related
Ensembl:ENSMUSG00000037720 AllianceGenome:MGI:1915128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
db83; 1110006G02Rik; 1600019D15Rik; 2410089A21Rik; 2700052H22Rik; 5430406L04Rik
Summary
Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; positive regulation of endoplasmic reticulum unfolded protein response; and regulation of endoplasmic reticulum tubular network organization. Predicted to be located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; nasal cavity epithelium; retina; submandibular gland primordium; and trigeminal nerve. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.1), whole brain E14.5 (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.1; 5 36.0 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67417908..67448804)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67260565..67291461)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:67623014-67623314 Neighboring gene predicted gene, 33293 Neighboring gene predicted gene, 40314 Neighboring gene STARR-positive B cell enhancer ABC_E3579 Neighboring gene STARR-seq mESC enhancer starr_13313 Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Slc30a9 Neighboring gene solute carrier family 30 (zinc transporter), member 9 Neighboring gene STARR-seq mESC enhancer starr_13315 Neighboring gene STARR-seq mESC enhancer starr_13316 Neighboring gene BEN domain containing 4 Neighboring gene predicted gene, 33345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, et al. Nat Commun, 2019 May 2. PMID 31048699, Free PMC Article
  2. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
  3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
  4. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
  5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285452.1 → NP_001272381.1  transmembrane protein 33 isoform 1

    See identical proteins and their annotated locations for NP_001272381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC102896, AK005493, AK012413, AK139978, AK165369, CJ103460
    Consensus CDS
    CCDS19317.1
    UniProtKB/Swiss-Prot
    Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
    Related
    ENSMUSP00000124390.2, ENSMUST00000161369.3
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

  2. NM_028975.4 → NP_083251.2  transmembrane protein 33 isoform 1

    See identical proteins and their annotated locations for NP_083251.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC102896, AK012413, AK017281, AK139978, AK165369
    Consensus CDS
    CCDS19317.1
    UniProtKB/Swiss-Prot
    Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
    Related
    ENSMUSP00000042852.6, ENSMUST00000037918.12
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

  3. NM_030108.2 → NP_084384.1  transmembrane protein 33 isoform 2

    See identical proteins and their annotated locations for NP_084384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 3. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102896, AK012413, AK017281, AK139978
    Consensus CDS
    CCDS51511.1
    UniProtKB/TrEMBL
    A0A0R4J1Z3
    Related
    ENSMUSP00000124766.2, ENSMUST00000160352.8
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    67417908..67448804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR67.1 GenPept UniProtKB/Swiss-Prot:Q9CR67

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