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Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 67877, updated on 5-Mar-2024

Summary

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Official Symbol
Naa20provided by MGI
Official Full Name
N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by MGI
Primary source
MGI:MGI:1915127
See related
Ensembl:ENSMUSG00000002728 AllianceGenome:MGI:1915127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nat5; D2Ertd186e; 1500004D14Rik; 2900026I01Rik
Summary
Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Is expressed in several structures, including alimentary system; brain; heart; retina; and skin. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.7), placenta adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145743454..145758345)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145901539..145916425)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2 Neighboring gene STARR-seq mESC enhancer starr_05932 Neighboring gene predicted gene, 54121 Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene predicted gene, 39954 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5996 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:145783203-145783504 Neighboring gene STARR-seq mESC enhancer starr_05934 Neighboring gene cilia and flagella associated protein 61 Neighboring gene STARR-seq mESC enhancer starr_05935 Neighboring gene predicted gene, 34629

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs. Elurbide J, et al. Int J Mol Sci, 2023 May 13. PMID 37240070, Free PMC Article
  2. Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. Ametzazurra A, et al. Oncogene, 2008 Dec 11. PMID 18794801
  3. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Kuo HP, et al. Sci Signal, 2010 Feb 9. PMID 20145209, Free PMC Article
  4. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Arnesen T, et al. Gene, 2006 Apr 26. PMID 16507339
  5. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Ohyama K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22101279

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
    Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
  2. Mdm20 is not necessarily co-expressed with Nat5 in the developing mouse brain.
    Title: Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.
  3. ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development
    Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144325

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-aspartic acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-glutamic acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-glutamine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatB complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 20
Names
N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
N-terminal acetyltransferase B complex catalytic subunit NAA20
N-terminal acetyltransferase B complex catalytic subunit NAT5
methionine N-acetyltransferase
natB catalytic subunit
natB complex subunit NAT5
NP_001135437.1
NP_080701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141965.1 → NP_001135437.1  N-alpha-acetyltransferase 20 isoform 1

    See identical proteins and their annotated locations for NP_001135437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK005143, AK009229, CO802916
    Consensus CDS
    CCDS50735.1
    UniProtKB/Swiss-Prot
    P61600, Q14B28, Q4VAC3
    Related
    ENSMUSP00000105627.2, ENSMUST00000110000.8
    Conserved Domains (1) summary
    COG0456
    Location:1 → 156
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  2. NM_026425.3 → NP_080701.1  N-alpha-acetyltransferase 20 isoform 2

    See identical proteins and their annotated locations for NP_080701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an in-frame alternate splice site in the coding region, compared to variant 1, and encodes a longer protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK005143, AK009229, CO802916
    Consensus CDS
    CCDS16827.1
    UniProtKB/TrEMBL
    Q9DB82
    Related
    ENSMUSP00000002805.8, ENSMUST00000002805.14
    Conserved Domains (1) summary
    COG0456
    Location:1 → 166
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145743454..145758345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953700.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61600.1 GenPept UniProtKB/Swiss-Prot:P61600

Gene LinkOut

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