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Mrrf mitochondrial ribosome recycling factor [ Mus musculus (house mouse) ]

Gene ID: 67871, updated on 11-Apr-2024

Summary

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Official Symbol
Mrrfprovided by MGI
Official Full Name
mitochondrial ribosome recycling factorprovided by MGI
Primary source
MGI:MGI:1915121
See related
Ensembl:ENSMUSG00000026887 AllianceGenome:MGI:1915121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RRF; MRFF; MTRRF; 2400002D02Rik
Summary
Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome disassembly and translation. Located in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.0), heart adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 24.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (36025672..36080296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36135660..36190284)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox protein 6 Neighboring gene RNA binding motif protein 18 Neighboring gene predicted gene, 46735 Neighboring gene STARR-positive B cell enhancer ABC_E5908 Neighboring gene prostaglandin-endoperoxide synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosome-recycling factor, mitochondrial
Names
ribosome-releasing factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026422.2 → NP_080698.1  ribosome-recycling factor, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080698.1

    Status: VALIDATED

    Source sequence(s)
    AK010018, BX293557, BY320901, CX237338
    Consensus CDS
    CCDS38114.1
    UniProtKB/Swiss-Prot
    B1B055, Q9D6S7
    Related
    ENSMUSP00000028250.3, ENSMUST00000028250.9
    Conserved Domains (1) summary
    pfam01765
    Location:99 → 260
    RRF; Ribosome recycling factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    36025672..36080296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251998.1 → XP_030107858.1  ribosome-recycling factor, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam01765
    Location:12 → 169
    RRF; Ribosome recycling factor

  2. XM_017319228.2 → XP_017174717.1  ribosome-recycling factor, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam01765
    Location:62 → 208
    RRF; Ribosome recycling factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6S7.1 GenPept UniProtKB/Swiss-Prot:Q9D6S7

Gene LinkOut

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