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Paip2 polyadenylate-binding protein-interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 67869, updated on 5-Mar-2024

Summary

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Official Symbol
Paip2provided by MGI
Official Full Name
polyadenylate-binding protein-interacting protein 2provided by MGI
Primary source
MGI:MGI:1915119
See related
Ensembl:ENSMUSG00000037058 AllianceGenome:MGI:1915119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310050K10Rik
Summary
Enables mRNA binding activity. Acts upstream of or within several processes, including memory; negative regulation of translation; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in embryo and retina. Orthologous to human PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 36.3), CNS E14 (RPKM 35.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Paip2 in Genome Data Viewer
Location:
18 B2; 18 19.16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35731649..35750239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35598610..35617186)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 1949 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene matrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9973 Neighboring gene STARR-positive B cell enhancer ABC_E5651 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene proline rich basic protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2). Rosenfeld AB. PLoS One, 2011. PMID 21957478, Free PMC Article
  2. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Khoutorsky A, et al. Neuron, 2013 Apr 24. PMID 23622065
  3. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Delbes G, et al. Biol Reprod, 2012 Mar. PMID 22190698
  4. The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. Yanagiya A, et al. J Clin Invest, 2010 Sep. PMID 20739757, Free PMC Article
  5. Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. Onesto C, et al. J Biol Chem, 2004 Aug 13. PMID 15175342

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study demonstrated that activity-dependent degradation of PAIP2A relieves translational inhibition of memory-related genes through PABP reactivation and conclude that PAIP2A is a pivotal translational regulator of synaptic plasticity and memory.
    Title: Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
  2. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.
    Title: PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.
  3. Paip2 is able to function as a tumor suppressor
    Title: Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
  4. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis
    Title: Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein-interacting protein 2
Names
PAIP-2
Pabp-interacting protein 2
poly(A)-binding protein-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357470.1 → NP_001344399.1  polyadenylate-binding protein-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    AC121821, AI449635
    Consensus CDS
    CCDS29143.1
    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000157742.2, ENSMUST00000236020.2
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  2. NM_001357471.1 → NP_001344400.1  polyadenylate-binding protein-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    AC121821, AI449635
    Consensus CDS
    CCDS29143.1
    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000157456.2, ENSMUST00000236868.2
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  3. NM_001357472.1 → NP_001344401.1  polyadenylate-binding protein-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    AC121821, AI449635
    Consensus CDS
    CCDS29143.1
    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000157519.2, ENSMUST00000235400.2
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  4. NM_001357473.1 → NP_001344402.1  polyadenylate-binding protein-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    AC121821, AEKQ02058005, AI449635
    Consensus CDS
    CCDS29143.1
    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  5. NM_026420.3 → NP_080696.1  polyadenylate-binding protein-interacting protein 2

    See identical proteins and their annotated locations for NP_080696.1

    Status: VALIDATED

    Source sequence(s)
    AI449635, AK009909, BB842021
    Consensus CDS
    CCDS29143.1
    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000036021.9, ENSMUST00000041314.17
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35731649..35750239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317973.3 → XP_017173462.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  2. XM_030250580.2 → XP_030106440.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  3. XM_036161261.1 → XP_036017154.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000158496.2, ENSMUST00000235476.2
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  4. XM_036161263.1 → XP_036017156.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Related
    ENSMUSP00000157936.2, ENSMUST00000235210.2
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  5. XM_036161264.1 → XP_036017157.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  6. XM_030250581.2 → XP_030106441.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UBH5, Q9D6V8, Q9DAW7
    UniProtKB/TrEMBL
    Q3TJ84, Q3U438
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6V8.1 GenPept UniProtKB/Swiss-Prot:Q9D6V8

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