Echdc3 enoyl Coenzyme A hydratase domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Echdc3provided by MGI
Official Full Name: enoyl Coenzyme A hydratase domain containing 3provided by MGI
Primary source: MGI:MGI:1915106
See related: Ensembl:ENSMUSG00000039063 AllianceGenome:MGI:1915106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310005D12Rik
Summary: Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid metabolic process and positive regulation of cellular response to insulin stimulus. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Orthologous to human ECHDC3 (enoyl-CoA hydratase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 51.3), liver E18 (RPKM 34.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 3.62 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (6193276..6217805, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (6188465..6212994, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enoyl-CoA hydratase activity	ISO Inferred from Sequence Orthology more info
enables hydro-lyase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: enoyl-CoA hydratase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024208.4 → NP_077170.2 enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor

See identical proteins and their annotated locations for NP_077170.2

Status: PROVISIONAL

Source sequence(s)

AK009166

Consensus CDS

CCDS15672.1

UniProtKB/Swiss-Prot

Q99LV0, Q9D7J9

Related

ENSMUSP00000037371.3, ENSMUST00000042658.5

Conserved Domains (1) summary

cl23717
Location:35 → 299

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...