Rab32 RAB32, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab32provided by MGI
Official Full Name: RAB32, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1915094
See related: Ensembl:ENSMUSG00000019832 AllianceGenome:MGI:1915094
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810011A17Rik
Summary: Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-3 adaptor complex binding activity; and BLOC-2 complex binding activity. Predicted to be involved in several processes, including endosome to melanosome transport; melanosome assembly; and phagosome maturation. Located in melanosome. Is expressed in duodenum; ileum; metanephros; prostate gland; and testis. Orthologous to human RAB32 (RAB32, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.2), liver adult (RPKM 10.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 3.44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (10420783..10433951, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (10545039..10558207, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts.
Title: Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts.
Rab32/38-Dependent and -Independent Transport of Tyrosinase to Melanosomes in B16-F1 Melanoma Cells.
Title: Rab32/38-Dependent and -Independent Transport of Tyrosinase to Melanosomes in B16-F1 Melanoma Cells.
VARP and Rab9 Are Dispensable for the Rab32/BLOC-3 Dependent Salmonella Killing.
Title: VARP and Rab9 Are Dispensable for the Rab32/BLOC-3 Dependent Salmonella Killing.
our study demonstrates the absence of impact of RAB38 or RAB32 single deficiency in platelet biogenesis and function resulting from full redundancy, and characterized a new mouse model mimicking HPS devoid of DG content.
Title: Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Rab32 plays an important role in mediating antimicrobial activity by promoting phagosome maturation at an early phase of infection with B. pseudomallei.
Title: Rab32 GTPase, as a direct target of miR-30b/c, controls the intracellular survival of Burkholderia pseudomallei by regulating phagosome maturation.
Rab32 represents a general cell-autonomous, antimicrobial defense that is counteracted by two Salmonella effectors.
Title: A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.
Rab32 could improve the induction of iPSCs through the enhancement of lipid biosynthesis, highlighting the importance of lipid metabolism during reprogramming.
Title: Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming.
antimicrobial functions in macromolecular complex results in bacterial containment
Title: Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Data suggest RUTBC1/SGSM2 in melanocytes functions as physiological GTPase-activating protein for Rab32/Rab38 in regulation of transport of melanogenic enzymes (tyrosinase, tyrosinase-related protein 1, dopachrome isomerase) into melanosomes.
Title: RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
RNA interference-mediated depletion of Rab32 or of an essential component of a BLOC complex was sufficient to allow S. Typhi to survive within mouse macrophages.
Title: A Rab32-dependent pathway contributes to Salmonella typhi host restriction.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab32 (e-PCR), detects polymorphism
- UniSTS:527513

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AP-1 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables AP-3 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables BLOC-2 complex binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome assembly	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026405.3 → NP_080681.1 ras-related protein Rab-32

See identical proteins and their annotated locations for NP_080681.1

Status: PROVISIONAL

Source sequence(s)

AK088661

Consensus CDS

CCDS23695.1

UniProtKB/Swiss-Prot

Q3TXU7, Q8BVD3, Q91YN4, Q9CZE3

UniProtKB/TrEMBL

Q0PD23, Q3TW01

Related

ENSMUSP00000019974.4, ENSMUST00000019974.5

Conserved Domains (2) summary

smart00175
Location:24 → 193

RAB; Rab subfamily of small GTPases

cd04107
Location:24 → 222

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)