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Mrpl57 mitochondrial ribosomal protein L57 [ Mus musculus (house mouse) ]

Gene ID: 67840, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl57provided by MGI
Official Full Name
mitochondrial ribosomal protein L57provided by MGI
Primary source
MGI:MGI:1915090
See related
Ensembl:ENSMUSG00000021967 AllianceGenome:MGI:1915090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrp63; 2610025P17Rik
Summary
A structural constituent of ribosome. Acts upstream of or within translation. Located in mitochondrial ribosome. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL57 (mitochondrial ribosomal protein L57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.2), adrenal adult (RPKM 13.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 30.51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58063662..58066544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57826228..57829087)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 52140 Neighboring gene STARR-seq mESC enhancer starr_36815 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene predicted gene, 22738 Neighboring gene zinc finger, DHHC domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitochondrial ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL63
Names
mMRP63
mitochondrial ribosomal protein 63
mitochondrial ribosomal protein L53
ribosomal protein 63, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026401.2 → NP_080677.1  large ribosomal subunit protein mL63

    See identical proteins and their annotated locations for NP_080677.1

    Status: PROVISIONAL

    Source sequence(s)
    AK011558
    Consensus CDS
    CCDS27161.1
    UniProtKB/Swiss-Prot
    Q9CQF8
    Related
    ENSMUSP00000022538.4, ENSMUST00000022538.5
    Conserved Domains (1) summary
    pfam14978
    Location:14 → 101
    MRP-63; Mitochondrial ribosome protein 63

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    58063662..58066544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519478.2 → XP_006519541.1  large ribosomal subunit protein mL63 isoform X1

    See identical proteins and their annotated locations for XP_006519541.1

    UniProtKB/Swiss-Prot
    Q9CQF8
    Conserved Domains (1) summary
    pfam14978
    Location:14 → 101
    MRP-63; Mitochondrial ribosome protein 63
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQF8.1 GenPept UniProtKB/Swiss-Prot:Q9CQF8

Gene LinkOut

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