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Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 [ Mus musculus (house mouse) ]

Gene ID: 67838, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajb11provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B11provided by MGI
Primary source
MGI:MGI:1915088
See related
Ensembl:ENSMUSG00000004460 AllianceGenome:MGI:1915088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dj9; ERdj3; ERj3p; ABBP-2; 1810031F23Rik
Summary
Enables signaling receptor binding activity and unfolded protein binding activity. Acts upstream of or within mRNA modification and negative regulation of neurogenesis. Located in cytoplasm; extracellular space; and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in polycystic kidney disease. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 25.6), liver E14 (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 13.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22676595..22698384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22857845..22879634)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30416 Neighboring gene crystallin, gamma S Neighboring gene TBCC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E484 Neighboring gene predicted gene, 30505 Neighboring gene alpha-2-HS-glycoprotein Neighboring gene predicted gene, 30611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. Genereux JC, et al. EMBO J, 2015 Jan 2. PMID 25361606, Free PMC Article
  2. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. Yu M, et al. J Biol Chem, 2000 Aug 11. PMID 10827079
  3. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Shen Y, et al. Mol Biol Cell, 2005 Jan. PMID 15525676, Free PMC Article
  4. Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. Marcinowski M, et al. Nat Struct Mol Biol, 2011 Feb. PMID 21217698
  5. A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing. Lau PP, et al. J Biol Chem, 2001 Dec 7. PMID 11584023

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neurogenesis IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of endoplasmic reticulum chaperone complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 11
Names
APOBEC1-binding protein 2
DnaJ (Hsp40) homolog, subfamily B, member 11
ER-associated Hsp40 co-chaperone
ER-associated dnaJ protein 3
ER-resident protein ERdj3
endoplasmic reticulum DNA J domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190804.1 → NP_001177733.1  dnaJ homolog subfamily B member 11 precursor

    See identical proteins and their annotated locations for NP_001177733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK050500, BY270762, BY617271, BY640220
    Consensus CDS
    CCDS28070.1
    UniProtKB/Swiss-Prot
    A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
    Related
    ENSMUSP00000004574.8, ENSMUST00000004574.14
    Conserved Domains (1) summary
    COG0484
    Location:22 → 344
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. NM_001190805.1 → NP_001177734.1  dnaJ homolog subfamily B member 11 precursor

    See identical proteins and their annotated locations for NP_001177734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK148511, BY270762, BY617271, BY625840, BY640220, CT027991
    Consensus CDS
    CCDS28070.1
    UniProtKB/Swiss-Prot
    A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
    Related
    ENSMUSP00000137542.2, ENSMUST00000178320.2
    Conserved Domains (1) summary
    COG0484
    Location:22 → 344
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  3. NM_026400.5 → NP_080676.3  dnaJ homolog subfamily B member 11 precursor

    See identical proteins and their annotated locations for NP_080676.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK148511, BY270762
    Consensus CDS
    CCDS28070.1
    UniProtKB/Swiss-Prot
    A6X957, Q543I7, Q8BK79, Q8VCY1, Q8VHB1, Q99KV1
    Related
    ENSMUSP00000126828.3, ENSMUST00000166487.10
    Conserved Domains (1) summary
    COG0484
    Location:22 → 344
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22676595..22698384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KV1.1 GenPept UniProtKB/Swiss-Prot:Q99KV1

Gene LinkOut

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