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Idh3a isocitrate dehydrogenase 3 (NAD+) alpha [ Mus musculus (house mouse) ]

Gene ID: 67834, updated on 11-Apr-2024

Summary

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Official Symbol
Idh3aprovided by MGI
Official Full Name
isocitrate dehydrogenase 3 (NAD+) alphaprovided by MGI
Primary source
MGI:MGI:1915084
See related
Ensembl:ENSMUSG00000032279 AllianceGenome:MGI:1915084
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110003P10Rik; 1500012E04Rik
Summary
Predicted to enable isocitrate dehydrogenase (NAD+) activity and magnesium ion binding activity. Predicted to be involved in NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 153.2), cerebellum adult (RPKM 51.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Idh3a in Genome Data Viewer
Location:
9 A5.3; 9 29.7 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54493795..54511946)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54586511..54604662)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24168 Neighboring gene Dmx-like 2 Neighboring gene STARR-seq mESC enhancer starr_24169 Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E888 Neighboring gene STARR-seq mESC enhancer starr_24171 Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene predicted gene, 51677 Neighboring gene predicted gene, 39341

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Findlay AS, et al. Dis Model Mech, 2018 Dec 18. PMID 30478029, Free PMC Article
  2. The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 31. PMID 28139779, Free PMC Article
  3. miR-9-5p regulates immunometabolic and epigenetic pathways in β-glucan-trained immunity via IDH3α. Su H, et al. JCI Insight, 2021 May 10. PMID 33986196, Free PMC Article
  4. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
  5. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-9-5p regulates immunometabolic and epigenetic pathways in beta-glucan-trained immunity via IDH3alpha.
    Title: miR-9-5p regulates immunometabolic and epigenetic pathways in β-glucan-trained immunity via IDH3α.
  2. the role of IDH3 in retinal disease and mitochondrial function, was investigated.
    Title: Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables isocitrate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isocitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Names
NAD(+)-specific ICDH subunit alpha
isocitric dehydrogenase subunit alpha
NP_083849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029573.2 → NP_083849.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083849.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049956
    Consensus CDS
    CCDS23191.1
    UniProtKB/Swiss-Prot
    Q3UAM8, Q8C8A1, Q9D1L1, Q9D6R2
    Related
    ENSMUSP00000127526.2, ENSMUST00000167866.2
    Conserved Domains (1) summary
    TIGR00175
    Location:29 → 362
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54493795..54511946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6R2.1 GenPept UniProtKB/Swiss-Prot:Q9D6R2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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