Rmdn3 regulator of microtubule dynamics 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rmdn3provided by MGI
Official Full Name: regulator of microtubule dynamics 3provided by MGI
Primary source: MGI:MGI:1915059
See related: Ensembl:ENSMUSG00000070730 AllianceGenome:MGI:1915059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rmd3; RMD-3; Fam82a2; Ptpip51; 1200015F23Rik
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in cellular calcium ion homeostasis. Predicted to act upstream of or within apoptotic process and cell differentiation. Located in mitochondrion. Is expressed in several structures, including eye. Orthologous to human RMDN3 (regulator of microtubule dynamics 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 12.0), placenta adult (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.94 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118967479..118987515, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119136998..119157034, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPIP51 as a therapeutic target for ischemic heart diseases.
Title: PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction.
Protein interaction profile of PTPIP51 suggests a role in the memory formation in the hippocampus and cerebellum.
Title: Memory and PTPIP51--a new protein in hippocampus and cerebellum.
PTPIP51(protein tyrosine phosphatase interacting protein 51) might serve as a linking protein in adipocyte metabolism by connecting the insulin receptor-triggered lipogenesis with the protein kinase A-dependent lipolysis.
Title: PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue.
The interaction of PTPIP51 with 14-3-3beta, especially in trained individuals, hints to an involvement of PTPIP51 in the downstream regulation of insulin action.
Title: PTPIP51 interaction with PTP1B and 14-3-3β in adipose tissue of insulin-resistant mice.
Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~79%.
Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
The data presented here suggest a role of PTPIP51 in neuronal homeostasis, axonal growth, and transport.
Title: Expression profile of PTPIP51 in mouse brain.
The PTPIP51 was integrated in signaling cascades regulating differentiation and apoptosis during eye development.
Title: Expression of PTPIP51 during mouse eye development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI131757 (e-PCR)
- UniSTS:159012

NoName (e-PCR)
- UniSTS:548169

NoName (e-PCR)
- UniSTS:548170

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of microtubule dynamics protein 3

Names: family with sequence similarity 82, member A2; microtubule-associated protein; protein tyrosine phosphatase-interacting protein 51; tyrosine phosphatase interacting protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.