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Rnls renalase, FAD-dependent amine oxidase [ Mus musculus (house mouse) ]

Gene ID: 67795, updated on 21-Apr-2024

Summary

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Official Symbol
Rnlsprovided by MGI
Official Full Name
renalase, FAD-dependent amine oxidaseprovided by MGI
Primary source
MGI:MGI:1915045
See related
Ensembl:ENSMUSG00000071573 AllianceGenome:MGI:1915045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C10orf59; 6530404N21Rik
Summary
Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in testis adult (RPKM 47.5), adrenal adult (RPKM 5.9) and 7 other tissues See more
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Genomic context

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Location:
19 C1; 19 29.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33115140..33369695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33137740..33392295, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29863 Neighboring gene predicted gene, 29946 Neighboring gene STARR-seq mESC enhancer starr_45963 Neighboring gene microRNA 3970 Neighboring gene STARR-positive B cell enhancer ABC_E11802 Neighboring gene predicted gene, 53225 Neighboring gene STARR-seq mESC enhancer starr_45967 Neighboring gene STARR-seq mESC enhancer starr_45968 Neighboring gene STARR-seq mESC enhancer starr_45969 Neighboring gene cullin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45970 Neighboring gene RIKEN cDNA 2810449D17 gene Neighboring gene STARR-seq mESC enhancer starr_45971 Neighboring gene STARR-seq mESC enhancer starr_45972 Neighboring gene predicted gene 7237 Neighboring gene STARR-seq mESC enhancer starr_45973 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model. Tokinoya K, et al. Mol Med Rep, 2021 Mar. PMID 33495844, Free PMC Article
  2. Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis. Tokinoya K, et al. Physiol Rep, 2020 Aug. PMID 32741114, Free PMC Article
  3. Renalase regulates peripheral and central dopaminergic activities. Quelhas-Santos J, et al. Am J Physiol Renal Physiol, 2015 Jan 15. PMID 25411385, Free PMC Article
  4. Renalase's expression and distribution in renal tissue and cells. Wang F, et al. PLoS One, 2012. PMID 23056310, Free PMC Article
  5. Identification, expression and tissue distribution of a renalase homologue from mouse. Wang J, et al. Mol Biol Rep, 2008 Dec. PMID 17846919

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
    Title: Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
  2. Protective Renalase Deficiency in beta-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes.
    Title: Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes.
  3. Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model.
    Title: Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model.
  4. Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase Pmca4b.
    Title: The serum protein renalase reduces injury in experimental pancreatitis.
  5. High RNLS expression is associated with melanoma.
    Title: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism.
  6. revealed renalase as a novel target gene of HIF-1alpha in protection against myocardial ischaemia/reperfusion injury
    Title: Renalase is a novel target gene of hypoxia-inducible factor-1 in protection against cardiac ischaemia-reperfusion injury.
  7. Renalase promotes cell survival and protects against renal injury in mice through the activation of intracellular signaling cascades, independent of its ability to metabolize catecholamines.
    Title: Renalase prevents AKI independent of amine oxidase activity.
  8. Renalase is wildly expressed in kidney, including glomeruli, tubule, mesangial cells, podocytes and tubule epithelial cells, and may be secreted by tubule epithelial cells primarily
    Title: Renalase's expression and distribution in renal tissue and cells.
  9. the identification of a renalase homologue from mouse, termed mMAO-C (mouse monoamine oxidase-C) after the monoamine oxidase-A and -B (MAO-A and -B
    Title: Identification, expression and tissue distribution of a renalase homologue from mouse.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH binding ISO
Inferred from Sequence Orthology
more info
  
enables epinephrine binding ISO
Inferred from Sequence Orthology
more info
  
enables monoamine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epinephrine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within norepinephrine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to norepinephrine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
renalase
Names
MAO-C
alpha-NAD(P)H oxidase/anomerase
monoamine oxidase-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368833.1 → NP_001355762.1  renalase precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the functional allele present in Kunming and other strains.
    Source sequence(s)
    AC125381, AC160088, DQ788834
    UniProtKB/Swiss-Prot
    A7RDN6, Q3TD88, Q80W75
    Conserved Domains (1) summary
    COG3380
    Location:1 → 342
    COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]

RNA

  1. NR_160911.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This transcript (1, non-coding) represents the non-coding allele present in the reference strain.
    Source sequence(s)
    AC117183, AC125381, AC160088
    Related
    ENSMUST00000096114.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    33115140..33369695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146342.2: Suppressed sequence

    Description
    NM_001146342.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  2. NM_181587.2: Suppressed sequence

    Description
    NM_181587.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7RDN6.2 GenPept UniProtKB/Swiss-Prot:A7RDN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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