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Sfr1 SWI5 dependent recombination repair 1 [ Mus musculus (house mouse) ]

Gene ID: 67788, updated on 5-Mar-2024

Summary

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Official Symbol
Sfr1provided by MGI
Official Full Name
SWI5 dependent recombination repair 1provided by MGI
Primary source
MGI:MGI:1915038
See related
Ensembl:ENSMUSG00000025066 AllianceGenome:MGI:1915038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meir5; 6330577E15Rik
Summary
Predicted to enable nuclear receptor coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 57.4), CNS E11.5 (RPKM 54.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D1; 19 40.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47720159..47724027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47731714..47735588)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26085 Neighboring gene predicted gene, 24805 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47805577-47805764 Neighboring gene STARR-positive B cell enhancer ABC_E8756 Neighboring gene STARR-seq mESC enhancer starr_46368 Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 8090 Neighboring gene STARR-seq mESC enhancer starr_46371 Neighboring gene STARR-positive B cell enhancer ABC_E2529 Neighboring gene STARR-seq mESC enhancer starr_46373 Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene predicted gene, 30021

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination. Su GC, et al. Nucleic Acids Res, 2016 Jul 27. PMID 27131790, Free PMC Article
  2. Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex. Tsai SP, et al. Nucleic Acids Res, 2012 Aug. PMID 22492707, Free PMC Article
  3. Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation. Lu CH, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30297419, Free PMC Article
  4. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Rousseaux MW, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019375, Free PMC Article
  5. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. Akamatsu Y, et al. PLoS Genet, 2010 Oct 14. PMID 20976249, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination.
    Title: Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.
  2. Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
    Title: Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.
  3. Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry.
    Title: Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.
  4. Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks.
    Title: Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Swi5-Sfr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Swi5-Sfr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Swi5-Sfr1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
swi5-dependent recombination DNA repair protein 1 homolog
Names
DNA repair protein Sfr1
meiosis protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026377.2 → NP_080653.2  swi5-dependent recombination DNA repair protein 1 homolog

    See identical proteins and their annotated locations for NP_080653.2

    Status: VALIDATED

    Source sequence(s)
    AK011531, AK146810, AV335878
    Consensus CDS
    CCDS38019.1
    UniProtKB/Swiss-Prot
    Q3TH62, Q3TI03, Q3TJK0, Q3UIQ6, Q8BP27, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4
    UniProtKB/TrEMBL
    E3WH30
    Related
    ENSMUSP00000096954.5, ENSMUST00000099353.6
    Conserved Domains (1) summary
    pfam10376
    Location:108 → 310
    Mei5; Double-strand recombination repair protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47720159..47724027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527308.4 → XP_006527371.1  swi5-dependent recombination DNA repair protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    E3WH30
    Conserved Domains (1) summary
    pfam10376
    Location:96 → 298
    Mei5; Double-strand recombination repair protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP27.2 GenPept UniProtKB/Swiss-Prot:Q8BP27

Gene LinkOut

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