Ddx47 DEAD box helicase 47 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx47provided by MGI
Official Full Name: DEAD box helicase 47provided by MGI
Primary source: MGI:MGI:1915005
See related: Ensembl:ENSMUSG00000030204 AllianceGenome:MGI:1915005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930588A18Rik
Summary: Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in RNA splicing; extrinsic apoptotic signaling pathway via death domain receptors; and rRNA processing. Predicted to act upstream of or within apoptotic process and mRNA processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human DDX47 (DEAD-box helicase 47). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 40.9), liver E14 (RPKM 29.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.77 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (134988575..135000739)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (135011612..135023776)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126139 (e-PCR)
- UniSTS:162851

NoName (e-PCR)
- UniSTS:235566

D12S1235E (e-PCR)
- UniSTS:151482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX47

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; DEAD box protein 47

NP_080636.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026360.3 → NP_080636.2 probable ATP-dependent RNA helicase DDX47

See identical proteins and their annotated locations for NP_080636.2

Status: VALIDATED

Source sequence(s)

AK010310, BB682132, BY123864

Consensus CDS

CCDS20643.1

UniProtKB/Swiss-Prot

Q9CWX9

UniProtKB/TrEMBL

A0A0N4SVT1, Q4VBG1

Related

ENSMUSP00000032326.5, ENSMUST00000032326.11

Conserved Domains (3) summary

PRK11192
Location:24 → 446

PRK11192; ATP-dependent RNA helicase SrmB; Provisional

cd00079
Location:237 → 366

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:26 → 227

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...