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ND2 NADH dehydrogenase subunit 2 [ Homo sapiens neanderthalensis (Neandertal) ]

Gene ID: 6775094, updated on 18-Aug-2023

Summary

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Gene symbol
ND2
Gene description
NADH dehydrogenase subunit 2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens neanderthalensis (common: Neandertal, sub-species: neanderthalensis)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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Sequence:
Chromosome: MT; NC_011137.1 (4465..5506)

Chromosome MT - NC_011137.1Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met Neighboring gene tRNA-Trp Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011137.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protective Effect of Mitochondrial ND2 C5178A Gene Mutation on Cell and Mitochondrial Functions. Tian L, et al. Oxid Med Cell Longev, 2021. PMID 34336093, Free PMC Article
  2. Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactions. Barshad G, et al. Sci Rep, 2019 Jul 10. PMID 31292494, Free PMC Article
  3. Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population. Chen X, et al. BMC Med Genet, 2019 Jul 5. PMID 31277597, Free PMC Article
  4. NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Influences the Association of Coffee Consumption with Serum Chloride Levels in Male Japanese Health Checkup Examinees: An Exploratory Cross-Sectional Analysis. Kokaze A, et al. Nutrients, 2018 Sep 20. PMID 30241386, Free PMC Article
  5. Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort. Li Y, et al. PLoS One, 2015. PMID 26340450, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial ND1 T4216C and ND2 C5178A mutations are associated with maternally transmitted diabetes mellitus.
    Title: Mitochondrial ND1 T4216C and ND2 C5178A mutations are associated with maternally transmitted diabetes mellitus.
  2. Protective Effect of Mitochondrial ND2 C5178A Gene Mutation on Cell and Mitochondrial Functions.
    Title: Protective Effect of Mitochondrial ND2 C5178A Gene Mutation on Cell and Mitochondrial Functions.
  3. Pediatric leukemia could be driven predominantly by non-synonymous variants in mitochondrial complex V in Mizo population from Northeast India.
    Title: Pediatric leukemia could be driven predominantly by non-synonymous variants in mitochondrial complex V in Mizo population from Northeast India.
  4. Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactions.
    Title: Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactions.
  5. ND2 5178 A allele could confer a lower risk for essential hypertension in Chinese by the interaction with smoking status. The higher risk of hypertension imposed by smoking and high TG may be altered by ND2 5178 A allele.
    Title: Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population.
  6. ND2-237 Leu/Met polymorphism modifies the association of coffee consumption with serum chloride levels in middle-aged Japanese men.
    Title: NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Influences the Association of Coffee Consumption with Serum Chloride Levels in Male Japanese Health Checkup Examinees: An Exploratory Cross-Sectional Analysis.
  7. The present study revealed no association between MS and A4917G variation in the mtDNA ND2 gene in the Iranian population.
    Title: Mitochondrial DNA T4216C and A4917G variations in multiple sclerosis.
  8. Variations in the mitochondrial genome and particularly in the mitochondrial ND2 gene may play a role in colorectal cancer risk among European Americans, but not in other maternal racial/ethnic groups.
    Title: Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.
  9. the frequency of 5178A was significantly decreased in male Parkinson disease patients in a Han Chinese population.
    Title: Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.
  10. The present results suggest that ND2-237 Leu/Met polymorphism unexpectedly modifies the effects of green tea consumption on estimated glomerular filtration rate.
    Title: Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.
Submit: New GeneRIF Correction See all GeneRIFs (16)

General protein information

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Preferred Names
NADH dehydrogenase subunit 2
YP_002124303.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011137.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002124303.1 NADH dehydrogenase subunit 2 (mitochondrion) [Homo sapiens neanderthalensis]

    See identical proteins and their annotated locations for YP_002124303.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H0EXE8, A0A7G5XR53, B4F436, C7BWU9, E1B2G8, Q36733
    Conserved Domains (1) summary
    MTH00105
    Location:1 → 345
    ND2; NADH dehydrogenase subunit 2; Provisional
Nucleotide Protein
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