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COX2 cytochrome c oxidase subunit II [ Homo sapiens neanderthalensis (Neandertal) ]

Gene ID: 6775079, updated on 18-Aug-2023

Summary

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Gene symbol
COX2
Gene description
cytochrome c oxidase subunit II
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens neanderthalensis (common: Neandertal, sub-species: neanderthalensis)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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Sequence:
Chromosome: MT; NC_011137.1 (7581..8264)

Chromosome MT - NC_011137.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit I Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011137.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cigarette smoke is associated with up-regulation of inducible NOS and COX-2 protein expression and activity in granulosa cells of women undergoing in vitro fertilization. Budani MC, et al. Reprod Toxicol, 2022 Oct. PMID 36049621
  2. c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner. Wang M, et al. ACS Chem Biol, 2021 Sep 17. PMID 34478263
  3. Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review). Gong Z, et al. Mol Med Rep, 2021 May. PMID 33760116, Free PMC Article
  4. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Gonçalves RM, et al. Cancer Lett, 2021 Apr 1. PMID 33429006
  5. Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging. Rodemerk J, et al. Stroke, 2020 Aug. PMID 32646326

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cigarette smoke is associated with up-regulation of inducible NOS and COX-2 protein expression and activity in granulosa cells of women undergoing in vitro fertilization.
    Title: Cigarette smoke is associated with up-regulation of inducible NOS and COX-2 protein expression and activity in granulosa cells of women undergoing in vitro fertilization.
  2. Aberrant Expression of COX-2 and FOXG1 in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors.
    Title: Aberrant Expression of COX-2 and FOXG1 in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors.
  3. Association of IL-1beta, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population.
    Title: Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population.
  4. c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner.
    Title: c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner.
  5. TGF-beta acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/beta-catenin pathways in colorectal cancer cells.
    Title: TGF-β acts as a dual regulator of COX-2/PGE(2) tumor promotion depending of its cross-interaction with H-Ras and Wnt/β-catenin pathways in colorectal cancer cells.
  6. MicroRNA-101 inhibits cadmium-induced angiogenesis by targeting cyclooxygenase-2 in primary human umbilical vein endothelial cells.
    Title: MicroRNA-101 inhibits cadmium-induced angiogenesis by targeting cyclooxygenase-2 in primary human umbilical vein endothelial cells.
  7. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice.
    Title: COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice.
  8. Upregulation of HIF1-alpha via an NF-kappaB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli.
    Title: Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli.
  9. Interplay between cyclooxygenase2 and microRNAs in cancer (Review).
    Title: Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review).
  10. BCL3 promotes cyclooxygenase2/prostaglandin E2 signalling in colorectal cancer.
    Title: BCL‑3 promotes cyclooxygenase‑2/prostaglandin E2 signalling in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (150)

General protein information

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Preferred Names
cytochrome c oxidase subunit II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011137.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002124305.1 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens neanderthalensis]

    See identical proteins and their annotated locations for YP_002124305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A343EQH2, A0A481MW37, A0A7G5XR55, B4F438, C7BWV1
    Conserved Domains (1) summary
    MTH00098
    Location:1 → 227
    COX2; cytochrome c oxidase subunit II; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials