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ATP6 ATP synthase F0 subunit 6 [ Homo sapiens neanderthalensis (Neandertal) ]

Gene ID: 6775074, updated on 18-Aug-2023

Summary

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Gene symbol
ATP6
Gene description
ATP synthase F0 subunit 6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens neanderthalensis (common: Neandertal, sub-species: neanderthalensis)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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Sequence:
Chromosome: MT; NC_011137.1 (8522..9202)

Chromosome MT - NC_011137.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly Neighboring gene NADH dehydrogenase subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011137.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells. D'Aurelio M, et al. Hum Mol Genet, 2010 Jan 15. PMID 19875463, Free PMC Article
  2. Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia. Ueno H, et al. Mitochondrion, 2009 Nov. PMID 19563917
  3. Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency. Venkatesh S, et al. Arch Gynecol Obstet, 2010 Sep. PMID 20361200
  4. Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology. Kucharczyk R, et al. Hum Mol Genet, 2009 Aug 1. PMID 19454486
  5. Accumulation of mitochondrial genome variations in Persian LQTS patients: a possible risk factor? Khatami M, et al. Cardiovasc Pathol, 2010 Mar-Apr. PMID 19369097

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association and genetic testing. (HuGE Navigator)
    Title: Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss.
  2. Observational study of genetic testing. (HuGE Navigator)
    Title: Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions.
  3. Mitochondrial DNA background modifies the bioenergetics of cells from retinitis pigmentosa and Leigh's syndrome patients carrying ATP6 mutations.
    Title: Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells.
  4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy.
  5. T9176G mutation of Atp6 is associated with the Leigh syndrome.
    Title: Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
ATP synthase F0 subunit 6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011137.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002124307.1 ATP synthase F0 subunit 6 (mitochondrion) [Homo sapiens neanderthalensis]

    See identical proteins and their annotated locations for YP_002124307.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1B0WVA3, A0A7G5XR57, B4F440
    Conserved Domains (1) summary
    MTH00101
    Location:1 → 226
    ATP6; ATP synthase F0 subunit 6; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials