Itgb3bp integrin beta 3 binding protein (beta3-endonexin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb3bpprovided by MGI
Official Full Name: integrin beta 3 binding protein (beta3-endonexin)provided by MGI
Primary source: MGI:MGI:1914983
See related: Ensembl:ENSMUSG00000028549 AllianceGenome:MGI:1914983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CENP-R; 4930471O16Rik
Summary: Predicted to be involved in CENP-A containing chromatin assembly and regulation of transcription, DNA-templated. Predicted to act upstream of or within apoptotic process and cell division. Predicted to be located in kinetochore and nucleus. Predicted to be active in nucleoplasm. Is expressed in brain; ovary; seminiferous tubule; spermatocyte; and spermatogonium. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 1.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.71 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (99655643..99717403, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (99767406..99829215, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate Cenp-r functions bilaterally in cancer development: during early developmental stages, Cenp-r functions as a tumor suppressor, but during the expansion and progression of papillomas it functions as a tumor-promoting factor
Title: CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model.
in contrast to uPAR or NF-kappaB, the expression of beta(3)-endonexin was reduced in extracts of advanced atherosclerotic aortic tissue
Title: Reduced beta3-endonexin levels are associated with enhanced urokinase-type plasminogen activator receptor expression in ApoE-/- mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: centromere protein R

Names: nuclear receptor-interacting factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362974.1 → NP_001349903.1 centromere protein R isoform 2

Status: VALIDATED

Source sequence(s)

AK165072

Conserved Domains (1) summary

pfam06729
Location:8 → 85

CENP-R; Kinetochore component, CENP-R
NM_001362975.1 → NP_001349904.1 centromere protein R isoform 3

Status: VALIDATED

Source sequence(s)

BX005053, BX324127

Conserved Domains (1) summary

pfam06729
Location:8 → 84

CENP-R; Kinetochore component, CENP-R
NM_001362976.1 → NP_001349905.1 centromere protein R isoform 4

Status: VALIDATED

Source sequence(s)

BX005053, BX324127

Related

ENSMUST00000102786.11

Conserved Domains (1) summary

pfam06729
Location:1 → 77

CENP-R; Kinetochore component, CENP-R
NM_026348.4 → NP_080624.1 centromere protein R isoform 1

See identical proteins and their annotated locations for NP_080624.1

Status: VALIDATED

Source sequence(s)

AK045037, AK165072

Consensus CDS

CCDS18387.1

UniProtKB/Swiss-Prot

Q3TLR0, Q3TNR4, Q9CQ82

Related

ENSMUSP00000117153.2, ENSMUST00000146258.2

Conserved Domains (1) summary

pfam06729
Location:25 → 161

CENP-R; Kinetochore component, CENP-R

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

99655643..99717403 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240600.4 → XP_011238902.1 centromere protein R isoform X1

Conserved Domains (1) summary

pfam06729
Location:27 → 162

CENP-R; Kinetochore component, CENP-R