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Dph2 DPH2 homolog [ Mus musculus (house mouse) ]

Gene ID: 67728, updated on 5-Mar-2024

Summary

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Official Symbol
Dph2provided by MGI
Official Full Name
DPH2 homologprovided by MGI
Primary source
MGI:MGI:1914978
See related
Ensembl:ENSMUSG00000028540 AllianceGenome:MGI:1914978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dph2l2; 9130020C19Rik
Summary
Predicted to enable 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Is expressed in liver lobe. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.0), spleen adult (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117745838..117749220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117888643..117892003, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 Neighboring gene predicted gene, 40233 Neighboring gene predicted gene 12841 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit B Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene importin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene artemin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Liu S, et al. Mol Cell Biol, 2004 Nov. PMID 15485916, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein histidyl modification to diphthamide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein histidyl modification to diphthamide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Names
DPH2-like 2
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase DPH2
diphthamide biosynthesis protein 2 homolog-like 2
diphtheria toxin resistance protein 2
diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1
diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 2
NP_001406090.1
NP_080620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419161.1 → NP_001406090.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627128

  2. NM_026344.4 → NP_080620.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_080620.1

    Status: VALIDATED

    Source sequence(s)
    AL627128
    Consensus CDS
    CCDS18541.1
    UniProtKB/Swiss-Prot
    Q8K0L8, Q9CR25
    Related
    ENSMUSP00000030265.4, ENSMUST00000030265.4
    Conserved Domains (1) summary
    TIGR00322
    Location:32 → 368
    diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117745838..117749220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR25.1 GenPept UniProtKB/Swiss-Prot:Q9CR25

Gene LinkOut

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