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Nudt13 nudix hydrolase 13 [ Mus musculus (house mouse) ]

Gene ID: 67725, updated on 5-Mar-2024

Summary

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Official Symbol
Nudt13provided by MGI
Official Full Name
nudix hydrolase 13provided by MGI
Primary source
MGI:MGI:1914975
See related
Ensembl:ENSMUSG00000021809 AllianceGenome:MGI:1914975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933433B15Rik
Summary
Enables NADH pyrophosphatase activity. Involved in NADH metabolic process and NADP catabolic process. Located in mitochondrion. Is expressed in brain; endocrine gland; genitourinary system; and trachea. Orthologous to human NUDT13 (nudix hydrolase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.1), bladder adult (RPKM 3.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nudt13 in Genome Data Viewer
Location:
14 A3; 14 11.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20344709..20367652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20294679..20317584)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 17 pseudogene Neighboring gene potassium channel, subfamily K, member 16 Neighboring gene STARR-positive B cell enhancer ABC_E1470 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_36108 Neighboring gene STARR-positive B cell enhancer ABC_E7295 Neighboring gene family with sequence similarity 149, member B Neighboring gene predicted gene, 30054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity. Abdelraheim SR, et al. Protein J, 2017 Oct. PMID 28755312, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH pyrophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)H pyrophosphatase NUDT13, mitochondrial
Names
nucleoside diphosphate-linked moiety X motif 13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
nudix motif 13
NP_001346797.1
NP_001346798.1
NP_001346799.1
NP_080617.2
XP_006519526.1
XP_006519531.1
XP_006519534.1
XP_011243461.1
XP_011243466.1
XP_030103834.1
XP_036014722.1
XP_036014723.1
XP_036014724.1
XP_036014725.1
XP_036014726.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359868.1 → NP_001346797.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49 → 360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  2. NM_001359869.1 → NP_001346798.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    Conserved Domains (2) summary
    pfam09296
    Location:63 → 179
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:183 → 212
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

  3. NM_001359870.1 → NP_001346799.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BQ749237
    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  4. NM_026341.3 → NP_080617.2  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_080617.2

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    Consensus CDS
    CCDS36815.1
    UniProtKB/Swiss-Prot
    Q8JZU0, Q9CXN4
    UniProtKB/TrEMBL
    Q80VI7
    Related
    ENSMUSP00000022343.5, ENSMUST00000022343.6
    Conserved Domains (4) summary
    COG2816
    Location:32 → 343
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd03429
    Location:200 → 343
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:46 → 162
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:166 → 195
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

RNA

  1. NR_153363.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK017031, AK161922, BB838132, BE987250
    Related
    ENSMUST00000225722.2

  2. NR_153364.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK017031, AK161922, BB838132, BE987250

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20344709..20367652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158831.1 → XP_036014724.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  2. XM_036158829.1 → XP_036014722.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49 → 360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  3. XM_011245159.2 → XP_011243461.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011243461.1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49 → 360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  4. XM_030247974.2 → XP_030103834.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  5. XM_011245164.2 → XP_011243466.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_011243466.1

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  6. XM_006519463.3 → XP_006519526.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006519526.1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:36 → 347
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  7. XM_006519468.5 → XP_006519531.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006519531.1

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  8. XM_036158830.1 → XP_036014723.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A286YE01
    Related
    ENSMUSP00000153437.2, ENSMUST00000223941.2
    Conserved Domains (2) summary
    pfam09296
    Location:47 → 162
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:166 → 195
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

  9. XM_036158833.1 → XP_036014726.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  10. XM_006519471.4 → XP_006519534.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006519534.1

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  11. XM_036158832.1 → XP_036014725.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1 → 217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

RNA

  1. XR_004938441.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZU0.2 GenPept UniProtKB/Swiss-Prot:Q8JZU0

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