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Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 [ Mus musculus (house mouse) ]

Gene ID: 67713, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc19provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C19provided by MGI
Primary source
MGI:MGI:1914963
See related
Ensembl:ENSMUSG00000027679 AllianceGenome:MGI:1914963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim14; 1810055D05Rik
Summary
Predicted to enable ATPase activator activity. Involved in regulation of cardiolipin metabolic process. Located in matrix side of mitochondrial inner membrane. Part of inner mitochondrial membrane protein complex. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 15.5), duodenum adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 16.43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (34111429..34135503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (34057280..34081354, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07364 Neighboring gene predicted gene, 46833 Neighboring gene STARR-seq mESC enhancer starr_07366 Neighboring gene calcium regulated heat stable protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07367 Neighboring gene FMR1 autosomal homolog 1 Neighboring gene STARR-seq mESC enhancer starr_07368 Neighboring gene SET translocation pseudogene Neighboring gene predicted gene, 52623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Richter-Dennerlein R, et al. Cell Metab, 2014 Jul 1. PMID 24856930
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cardiolipin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner mitochondrial membrane protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in matrix side of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit TIM14
Names
DnaJ (Hsp40) homolog, subfamily C, member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001026211.2 → NP_001021382.1  mitochondrial import inner membrane translocase subunit TIM14 isoform 2

    See identical proteins and their annotated locations for NP_001021382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC068294, AK008267, CA469052
    Consensus CDS
    CCDS38411.1
    UniProtKB/TrEMBL
    G3X8S1
    Related
    ENSMUSP00000011029.6, ENSMUST00000011029.12
    Conserved Domains (1) summary
    cl02542
    Location:55 → 94
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

  2. NM_001286972.1 → NP_001273901.1  mitochondrial import inner membrane translocase subunit TIM14 isoform3

    See identical proteins and their annotated locations for NP_001273901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a 3' terminal exon that extends past a splice site that is used in variant 2. This results in a novel 3' coding region and 3' UTR compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC068294, CA469052, EL962106
    Consensus CDS
    CCDS71233.1
    UniProtKB/Swiss-Prot
    Q9CQV7
    Related
    ENSMUSP00000113484.2, ENSMUST00000117223.4
    Conserved Domains (1) summary
    cl02542
    Location:55 → 94
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

  3. NM_001286973.1 → NP_001273902.1  mitochondrial import inner membrane translocase subunit TIM14 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 2. These differences result in a distinct 5' UTR and a different 3' structure and cause translation initiation at an alternate start codon compared to variant 2. The encoded protein (isoform 4) has distinct N- and C-termini and is shorter than isoform 2.
    Source sequence(s)
    AK007866, CA469052, CJ123658
    Consensus CDS
    CCDS71234.1
    UniProtKB/TrEMBL
    D3Z5K6
    Related
    ENSMUSP00000113514.2, ENSMUST00000120805.8
    Conserved Domains (1) summary
    cl02542
    Location:49 → 104
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

  4. NM_026332.4 → NP_080608.3  mitochondrial import inner membrane translocase subunit TIM14 isoform 1

    See identical proteins and their annotated locations for NP_080608.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 3' terminal exon which results in a frameshift compared to variant 2. The resulting protein (isoform 1) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC068294, AK007866, CA469052
    Consensus CDS
    CCDS38412.1
    UniProtKB/Swiss-Prot
    Q8R1N1, Q9CQV7, Q9D896
    Related
    ENSMUSP00000103830.4, ENSMUST00000108195.10
    Conserved Domains (1) summary
    cl02542
    Location:55 → 110
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    34111429..34135503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQV7.3 GenPept UniProtKB/Swiss-Prot:Q9CQV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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