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Stmp1 short transmembrane mitochondrial protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67705, updated on 21-Apr-2024

Summary

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Official Symbol
Stmp1provided by MGI
Official Full Name
short transmembrane mitochondrial protein 1provided by MGI
Primary source
MGI:MGI:1914955
See related
Ensembl:ENSMUSG00000073155 AllianceGenome:MGI:1914955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mm47; 1810058I24Rik
Summary
Involved in positive regulation of NLRP3 inflammasome complex assembly and positive regulation of interleukin-1 beta production. Located in mitochondrial intermembrane space and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 52.4), heart adult (RPKM 49.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 15.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (35229645..35238574)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (35252710..35261639)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:35141265-35141448 Neighboring gene nucleoporin 205 Neighboring gene STARR-seq mESC enhancer starr_15553 Neighboring gene STARR-seq mESC enhancer starr_15554 Neighboring gene predicted gene, 23435 Neighboring gene STARR-seq mESC enhancer starr_15555 Neighboring gene solute carrier family 13 (sodium/sulfate symporters), member 4 Neighboring gene family with sequence similarity 180, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation. Zheng X, et al. Biochem Biophys Res Commun, 2022 Dec 25. PMID 36368158
  2. A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome. Bhatta A, et al. J Immunol, 2020 Jan 15. PMID 31836654, Free PMC Article
  3. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Makarewich CA, et al. Proc Natl Acad Sci U S A, 2022 Feb 8. PMID 35101990, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation.
    Title: The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation.
  2. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice.
    Title: The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respirasome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respirasome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial respirasome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short transmembrane mitochondrial protein 1
Names
mitochondrial micropeptide-47
protein mitolamban

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384235.2 → NP_001371164.1  short transmembrane mitochondrial protein 1

    Status: VALIDATED

    Source sequence(s)
    AC158681
    UniProtKB/Swiss-Prot
    A0A5F8MPG2, P0DP99, Q3TAI1
    Related
    ENSMUSP00000158958.2, ENSMUST00000152147.8
    Conserved Domains (1) summary
    pfam15054
    Location:4 → 44
    DUF4535; Domain of unknown function (DUF4535)

RNA

  1. NR_169139.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158681

  2. NR_169140.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158681
    Related
    ENSMUST00000130875.8

  3. NR_169141.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158681

  4. NR_169142.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158681

  5. NR_169143.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158681

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    35229645..35238574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015608.1: Suppressed sequence

    Description
    NR_015608.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_027875.1: Suppressed sequence

    Description
    NR_027875.1: This RefSeq was removed by NCBI staff.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DP99.2 GenPept UniProtKB/Swiss-Prot:P0DP99

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.