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Rnf149 ring finger protein 149 [ Mus musculus (house mouse) ]

Gene ID: 67702, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf149provided by MGI
Official Full Name
ring finger protein 149provided by MGI
Primary source
MGI:MGI:2677438
See related
Ensembl:ENSMUSG00000048234 AllianceGenome:MGI:2677438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Greul4; Gm15832; 1600023E10Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human RNF149 (ring finger protein 149). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 52.2), liver adult (RPKM 14.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 18.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39590375..39616885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39551294..39577439, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene predicted gene, 18446 Neighboring gene STARR-seq mESC enhancer starr_00724 Neighboring gene predicted gene, 23722 Neighboring gene predicted gene, 51620 Neighboring gene predicted gene 5100 Neighboring gene cellular repressor of E1A-stimulated genes 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of RNF149 in the pre-emptive quality control substrate ubiquitination. Legesse A, et al. Commun Biol, 2023 Apr 8. PMID 37031316, Free PMC Article
  2. Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). Hong SW, et al. J Biol Chem, 2012 Jul 6. PMID 22628551, Free PMC Article
  3. Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice. Rouger K, et al. Am J Physiol Cell Physiol, 2002 Sep. PMID 12176734
  4. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366
  5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF149
Names
RING-type E3 ubiquitin transferase RNF149
goliath-related E3 ubiquitin-protein ligase 4
NP_001028307.2
XP_006496289.1
XP_036009047.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033135.3 → NP_001028307.2  E3 ubiquitin-protein ligase RNF149 precursor

    See identical proteins and their annotated locations for NP_001028307.2

    Status: VALIDATED

    Source sequence(s)
    AK005523, BE627920, BF018252, BY743657, CR759684
    Consensus CDS
    CCDS14907.1
    UniProtKB/Swiss-Prot
    E9QAH5, Q14BF0, Q3U2C5, Q8CGR2
    Related
    ENSMUSP00000050388.6, ENSMUST00000062525.11
    Conserved Domains (3) summary
    cd02122
    Location:45 → 181
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:263 → 306
    zf-RING_2; Ring finger domain
    cl11506
    Location:193 → 220
    UPF0233; uncharacterized protein family (UPF0233)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39590375..39616885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153154.1 → XP_036009047.1  E3 ubiquitin-protein ligase RNF149 isoform X1

    Conserved Domains (4) summary
    cd00162
    Location:108 → 148
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl28883
    Location:1 → 24
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cl11506
    Location:36 → 63
    CrgA; Cell division protein CrgA
    cl17238
    Location:107 → 154
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_006496226.5 → XP_006496289.1  E3 ubiquitin-protein ligase RNF149 isoform X1

    See identical proteins and their annotated locations for XP_006496289.1

    Conserved Domains (4) summary
    cd00162
    Location:108 → 148
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl28883
    Location:1 → 24
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cl11506
    Location:36 → 63
    CrgA; Cell division protein CrgA
    cl17238
    Location:107 → 154
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_373259.5 RNA Sequence

  2. XR_004934117.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U2C5.3 GenPept UniProtKB/Swiss-Prot:Q3U2C5

Gene LinkOut

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