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Aldh3b1 aldehyde dehydrogenase 3 family, member B1 [ Mus musculus (house mouse) ]

Gene ID: 67689, updated on 5-Mar-2024

Summary

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Official Symbol
Aldh3b1provided by MGI
Official Full Name
aldehyde dehydrogenase 3 family, member B1provided by MGI
Primary source
MGI:MGI:1914939
See related
Ensembl:ENSMUSG00000024885 AllianceGenome:MGI:1914939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALDH4; ALDH7; 1700001N19Rik
Summary
Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to act upstream of or within aldehyde catabolic process and cellular response to oxidative stress. Located in cytosol and plasma membrane. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 64.8), lung adult (RPKM 33.1) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Aldh3b1 in Genome Data Viewer
Location:
19 A; 19 3.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3963491..3980898, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3913491..3930898, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 Neighboring gene STARR-positive B cell enhancer ABC_E9987 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene predicted gene, 42059 Neighboring gene STARR-positive B cell enhancer ABC_E7624 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene STARR-seq mESC enhancer starr_45335 Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Marchitti SA, et al. Free Radic Biol Med, 2010 Nov 15. PMID 20699116, Free PMC Article
  2. Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Kitamura T, et al. Biochem J, 2015 Jan 1. PMID 25286108
  3. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Levi BP, et al. Blood, 2009 Feb 19. PMID 18971422, Free PMC Article
  4. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables benzaldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables benzaldehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aldehyde catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular aldehyde metabolic process IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase family 3 member B1
Names
aldehyde dehydrogenase 7
NP_080592.2
XP_006531893.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026316.3 → NP_080592.2  aldehyde dehydrogenase family 3 member B1

    See identical proteins and their annotated locations for NP_080592.2

    Status: VALIDATED

    Source sequence(s)
    BC046597, BY194399
    Consensus CDS
    CCDS29403.1
    UniProtKB/Swiss-Prot
    Q63ZW3, Q80VQ0, Q8VHW0, Q9CW05
    UniProtKB/TrEMBL
    Q3TX25, Q3U3J9
    Related
    ENSMUSP00000056276.7, ENSMUST00000051803.8
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3963491..3980898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531830.4 → XP_006531893.1  aldehyde dehydrogenase family 3 member B1 isoform X1

    See identical proteins and their annotated locations for XP_006531893.1

    UniProtKB/Swiss-Prot
    Q63ZW3, Q80VQ0, Q8VHW0, Q9CW05
    UniProtKB/TrEMBL
    Q3TX25, Q3U3J9
    Conserved Domains (1) summary
    cd07132
    Location:5 → 447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VQ0.1 GenPept UniProtKB/Swiss-Prot:Q80VQ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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