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Rpl38 ribosomal protein L38 [ Mus musculus (house mouse) ]

Gene ID: 67671, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl38provided by MGI
Official Full Name
ribosomal protein L38provided by MGI
Primary source
MGI:MGI:1914921
See related
Ensembl:ENSMUSG00000057322 AllianceGenome:MGI:1914921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ts; Rbt; Tss; 0610025G13Rik
Summary
Predicted to be a structural constituent of ribosome. Acts upstream of or within several processes, including 90S preribosome assembly; middle ear morphogenesis; and sensory perception of sound. Part of eukaryotic 80S initiation complex. Is active in synapse. Is expressed in thymus primordium. Used to study otitis media. Orthologous to human RPL38 (ribosomal protein L38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 322.3), liver E14 (RPKM 265.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl38 in Genome Data Viewer
Location:
11 79.82 cM; 11 E2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114558644..114563159)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114667818..114672333)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53653 Neighboring gene STARR-positive B cell enhancer ABC_E1151 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene tweety family member 2 Neighboring gene dynein axonemal intermediate chain 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114606533-114606834

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis. Shi L, et al. Inflamm Res, 2022 Aug. PMID 35596790
  2. A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. MORGAN WC. J Hered, 1950 Aug. PMID 14779008
  3. In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse. Paterson HF. J Exp Zool, 1980 Feb. PMID 7373273
  4. Fetal erythropoiesis and hemoglobin ontogeny in tail-short (Ts/+) mutant mice. Brotherton TW, et al. Blood, 1979 Sep. PMID 465735
  5. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. Noben-Trauth K, et al. J Biol Chem, 2011 Jan 28. PMID 21062742, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis.
    Title: RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis.
  2. Study identified mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of the axial skeleton.
    Title: Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.
  3. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.
    Title: Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 90S preribosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within axial mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-RNA complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 80S initiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL38
Names
60S ribosomal protein L38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048057.2 → NP_001041522.1  large ribosomal subunit protein eL38

    See identical proteins and their annotated locations for NP_001041522.1

    Status: VALIDATED

    Source sequence(s)
    AL645484, BC094258, BU921494, CJ042718
    Consensus CDS
    CCDS36365.1
    UniProtKB/Swiss-Prot
    Q9JJI8
    UniProtKB/TrEMBL
    Q52KP0
    Related
    ENSMUSP00000102211.2, ENSMUST00000077915.10
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

  2. NM_001048058.2 → NP_001041523.1  large ribosomal subunit protein eL38

    See identical proteins and their annotated locations for NP_001041523.1

    Status: VALIDATED

    Source sequence(s)
    AL645484, BE448083
    Consensus CDS
    CCDS36365.1
    UniProtKB/Swiss-Prot
    Q9JJI8
    UniProtKB/TrEMBL
    Q52KP0
    Related
    ENSMUSP00000080741.5, ENSMUST00000082092.5
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

  3. NM_001362918.1 → NP_001349847.1  large ribosomal subunit protein eL38

    Status: VALIDATED

    Source sequence(s)
    AL645484, BY687415
    Consensus CDS
    CCDS36365.1
    UniProtKB/Swiss-Prot
    Q9JJI8
    UniProtKB/TrEMBL
    Q52KP0
    Related
    ENSMUSP00000102209.2, ENSMUST00000106599.8
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

  4. NM_023372.3 → NP_075861.1  large ribosomal subunit protein eL38

    See identical proteins and their annotated locations for NP_075861.1

    Status: VALIDATED

    Source sequence(s)
    AL645484, BC094258, BU921494
    Consensus CDS
    CCDS36365.1
    UniProtKB/Swiss-Prot
    Q9JJI8
    UniProtKB/TrEMBL
    Q52KP0
    Related
    ENSMUSP00000102213.4, ENSMUST00000106602.10
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    114558644..114563159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314720.1 → XP_017170209.1  large ribosomal subunit protein eL38 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJI8
    UniProtKB/TrEMBL
    Q52KP0
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJI8.3 GenPept UniProtKB/Swiss-Prot:Q9JJI8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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