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Ctdp1 CTD phosphatase subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 67655, updated on 5-Mar-2024

Summary

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Official Symbol
Ctdp1provided by MGI
Official Full Name
CTD phosphatase subunit 1provided by MGI
Primary source
MGI:MGI:1926953
See related
Ensembl:ENSMUSG00000033323 AllianceGenome:MGI:1926953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930563P03Rik
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity; TFIIF-class transcription factor complex binding activity; and Tat protein binding activity. Predicted to be involved in several processes, including dephosphorylation of RNA polymerase II C-terminal domain; negative regulation of cell growth involved in cardiac muscle cell development; and positive regulation by host of viral transcription. Predicted to act upstream of or within cell division. Predicted to be located in microtubule cytoskeleton; midbody; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 3.7), ovary adult (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 53.48 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80451174..80522959, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80407959..80478739, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 2 Neighboring gene RIKEN cDNA D330025C20 gene Neighboring gene predicted gene, 29967 Neighboring gene STARR-seq mESC enhancer starr_45177 Neighboring gene predicted gene 9456 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:80689226-80689427 Neighboring gene predicted gene, 30020 Neighboring gene predicted gene, 41788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Qiao F, et al. Biol Open, 2021 Jan 6. PMID 33408128, Free PMC Article
  2. Human capping enzyme promotes formation of transcriptional R loops in vitro. Kaneko S, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17978174, Free PMC Article
  3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
    Title: Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables TFIIF-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA polymerase II subunit A C-terminal domain phosphatase
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
TFIIF-associating CTD phosphatase
NP_080571.2
XP_006526588.1
XP_011245398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026295.3 → NP_080571.2  RNA polymerase II subunit A C-terminal domain phosphatase

    See identical proteins and their annotated locations for NP_080571.2

    Status: VALIDATED

    Source sequence(s)
    BC053435, BY239926
    Consensus CDS
    CCDS29368.1
    UniProtKB/Swiss-Prot
    Q7TSG2, Q7TSS7, Q9D4S8
    UniProtKB/TrEMBL
    Q3U0S4
    Related
    ENSMUSP00000038938.7, ENSMUST00000036229.13
    Conserved Domains (4) summary
    TIGR02250
    Location:177 → 323
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    cd06850
    Location:27 → 111
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd00027
    Location:637 → 706
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam09309
    Location:706 → 960
    FCP1_C; FCP1, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80451174..80522959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526525.5 → XP_006526588.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

    UniProtKB/TrEMBL
    Q3U0S4
    Conserved Domains (4) summary
    TIGR02250
    Location:177 → 323
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    cd06850
    Location:27 → 111
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd17729
    Location:611 → 713
    BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins
    pfam09309
    Location:706 → 799
    FCP1_C; FCP1, C-terminal

  2. XM_011247096.2 → XP_011245398.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

    See identical proteins and their annotated locations for XP_011245398.1

    UniProtKB/TrEMBL
    Q3U0S4
    Conserved Domains (3) summary
    TIGR02250
    Location:58 → 204
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    cd17729
    Location:492 → 594
    BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins
    pfam09309
    Location:587 → 841
    FCP1_C; FCP1, C-terminal

RNA

  1. XR_003952539.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSG2.1 GenPept UniProtKB/Swiss-Prot:Q7TSG2

Gene LinkOut

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