U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Etfrf1 electron transfer flavoprotein regulatory factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67636, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Etfrf1provided by MGI
Official Full Name
electron transfer flavoprotein regulatory factor 1provided by MGI
Primary source
MGI:MGI:1914886
See related
Ensembl:ENSMUSG00000040370 AllianceGenome:MGI:1914886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghiso; Lyrm5; 4930469P12Rik
Summary
Predicted to be involved in respiratory electron transport chain. Located in mitochondrion. Is expressed in adrenal medulla. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.6), liver E18 (RPKM 9.5) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 G3; 6 77.37 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145156860..145162891)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145211134..145217368)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene Kirsten rat sarcoma viral oncogene homolog Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Galbiati F, et al. Cancer Lett, 2006 Dec 8. PMID 16458428
  2. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534
  3. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article
  4. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Manenti G, et al. Oncogene, 2004 May 27. PMID 15064703
  5. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Wang M, et al. Cancer Res, 2003 Jun 15. PMID 12810665

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ghiso is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
    Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
electron transfer flavoprotein regulatory factor 1
Names
LYR motif containing 5
LYR motif-containing protein 5
growth hormone-inducible soluble protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163628.1 → NP_001157100.1  electron transfer flavoprotein regulatory factor 1

    See identical proteins and their annotated locations for NP_001157100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091, CX203242
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107354.2, ENSMUST00000111725.8
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  2. NM_001362053.1 → NP_001348982.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the logest transcript. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  3. NM_001362054.1 → NP_001348983.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  4. NM_001362055.1 → NP_001348984.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107350.2, ENSMUST00000111721.2
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  5. NM_001362056.1 → NP_001348985.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091, AF412298
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000039433.4, ENSMUST00000039729.5
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  6. NM_001362057.1 → NP_001348986.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091, AF412299
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107353.2, ENSMUST00000111724.8
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  7. NM_001362058.1 → NP_001348987.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107348.2, ENSMUST00000111719.2
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  8. NM_001362059.1 → NP_001348988.1  electron transfer flavoprotein regulatory factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  9. NM_133688.3 → NP_598449.1  electron transfer flavoprotein regulatory factor 1

    See identical proteins and their annotated locations for NP_598449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157091, AF412300, AK075835
    Consensus CDS
    CCDS39706.1
    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107355.4, ENSMUST00000111726.10
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

RNA

  1. NR_155281.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate splice juinction and lacks an alternate exon compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC157091, BE848706

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145156860..145162891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152279.1 → XP_036008172.1  electron transfer flavoprotein regulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Related
    ENSMUSP00000107352.2, ENSMUST00000111723.8
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  2. XM_006506983.5 → XP_006507046.1  electron transfer flavoprotein regulatory factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507046.1

    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  3. XM_036152278.1 → XP_036008171.1  electron transfer flavoprotein regulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2KFC1, Q675B1, Q8VDL7, Q91V16
    Conserved Domains (1) summary
    cd20265
    Location:6 → 79
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91V16.1 GenPept UniProtKB/Swiss-Prot:Q91V16

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous