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Tm7sf3 transmembrane 7 superfamily member 3 [ Mus musculus (house mouse) ]

Gene ID: 67623, updated on 21-Apr-2024

Summary

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Official Symbol
Tm7sf3provided by MGI
Official Full Name
transmembrane 7 superfamily member 3provided by MGI
Primary source
MGI:MGI:1914873
See related
Ensembl:ENSMUSG00000040234 AllianceGenome:MGI:1914873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NARP1; 2010003B14Rik
Summary
Involved in cellular response to unfolded protein and negative regulation of programmed cell death. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human TM7SF3 (transmembrane 7 superfamily member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 11.6), limb E14.5 (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.7 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146503774..146536103, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146602276..146634605, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 13 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene STARR-positive B cell enhancer ABC_E1076 Neighboring gene mediator complex subunit 21 Neighboring gene RIKEN cDNA 4930479D17 gene Neighboring gene predicted pseudogene 6654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis. Wu YJ, et al. Parasit Vectors, 2021 Mar 10. PMID 33691755, Free PMC Article
  2. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Isaac R, et al. Cell Death Differ, 2017 Jan. PMID 27740623, Free PMC Article
  3. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. Beck A, et al. Diabetologia, 2011 Nov. PMID 21853325
  4. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534
  5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The NF-kappaB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
    Title: The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
  2. Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.
    Title: An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane 7 superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026281.2 → NP_080557.2  transmembrane 7 superfamily member 3 precursor

    See identical proteins and their annotated locations for NP_080557.2

    Status: VALIDATED

    Source sequence(s)
    AC124128, AK010720
    Consensus CDS
    CCDS20699.1
    UniProtKB/Swiss-Prot
    Q3TBQ2, Q3U3Q6, Q4F873, Q6PES5, Q9CRG1
    UniProtKB/TrEMBL
    A0A0R4J0K4
    Related
    ENSMUSP00000045650.10, ENSMUST00000037709.16
    Conserved Domains (1) summary
    pfam13886
    Location:291 → 498
    DUF4203; Domain of unknown function (DUF4203)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    146503774..146536103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255567.1 → XP_030111427.1  transmembrane 7 superfamily member 3 isoform X1

    Conserved Domains (1) summary
    pfam13886
    Location:79 → 286
    DUF4203; Domain of unknown function (DUF4203)

  2. XM_036152277.1 → XP_036008170.1  transmembrane 7 superfamily member 3 isoform X1

    Conserved Domains (1) summary
    pfam13886
    Location:79 → 286
    DUF4203; Domain of unknown function (DUF4203)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRG1.2 GenPept UniProtKB/Swiss-Prot:Q9CRG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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