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Mxra7 matrix-remodelling associated 7 [ Mus musculus (house mouse) ]

Gene ID: 67622, updated on 5-Mar-2024

Summary

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Official Symbol
Mxra7provided by MGI
Official Full Name
matrix-remodelling associated 7provided by MGI
Primary source
MGI:MGI:1914872
See related
Ensembl:ENSMUSG00000020814 AllianceGenome:MGI:1914872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810057P16Rik; E130302J09Rik
Summary
Predicted to be located in endoplasmic reticulum. Is expressed in ganglia; medulla oblongata basal plate mantle layer; retina; and trigeminal nerve. Orthologous to human MXRA7 (matrix remodeling associated 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 24.9), ovary adult (RPKM 13.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 81.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116694226..116718953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116803400..116828127, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC018473 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene jumonji domain containing 6 Neighboring gene methyltransferase like 23 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene major facilitator superfamily domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions. Shen Y, et al. Inflamm Regen, 2023 Jan 16. PMID 36647132, Free PMC Article
  2. [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells]. Zheng YD, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2022 Jun. PMID 35680791
  3. Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts. Zhou Z, et al. J Cell Physiol, 2019 Aug. PMID 30843215
  4. Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Lin D, et al. Front Immunol, 2018. PMID 29720975, Free PMC Article
  5. Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye. Jia C, et al. Gene, 2017 Oct 20. PMID 28847716

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells].
    Title: [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells].
  2. MXRA7 influences bone formation by regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells.
    Title: Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts.
  3. These data demonstrated that MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
    Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
  4. MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
    Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
  5. MXRA7 influences bone formation via regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells. Deficiency of MXRA7 in mice leads to shorter tibia.
    Title: Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts.
  6. We concluded that MXRA7 was an active player in CCl4-induced liver injury
    Title: Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
  7. MXRA7 is under-expressed during corneal infection and neovascularization.
    Title: Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix-remodeling-associated protein 7
Names
transmembrane anchor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347633.1 → NP_001334562.1  matrix-remodeling-associated protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645542, BC075618, BE982207
    Consensus CDS
    CCDS83937.1
    UniProtKB/TrEMBL
    Q9D1T2
    Related
    ENSMUSP00000038213.6, ENSMUST00000047715.12

  2. NM_026280.3 → NP_080556.1  matrix-remodeling-associated protein 7 isoform 1

    See identical proteins and their annotated locations for NP_080556.1

    Status: VALIDATED

    Source sequence(s)
    AK075801, CX734756
    Consensus CDS
    CCDS25677.1
    UniProtKB/Swiss-Prot
    A2AA24, B2RVR9, Q8C6F8, Q9CZH7
    Related
    ENSMUSP00000021170.3, ENSMUST00000021170.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116694226..116718953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534006.4 → XP_006534069.1  matrix-remodeling-associated protein 7 isoform X2

  2. XM_036156914.1 → XP_036012807.1  matrix-remodeling-associated protein 7 isoform X1

    UniProtKB/TrEMBL
    Q9D1T2

RNA

  1. XR_001780042.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZH7.2 GenPept UniProtKB/Swiss-Prot:Q9CZH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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