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Lrp2bp Lrp2 binding protein [ Mus musculus (house mouse) ]

Gene ID: 67620, updated on 5-Mar-2024

Summary

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Official Symbol
Lrp2bpprovided by MGI
Official Full Name
Lrp2 binding proteinprovided by MGI
Primary source
MGI:MGI:1914870
See related
Ensembl:ENSMUSG00000031637 AllianceGenome:MGI:1914870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MegBP; 1700113N17Rik; 2310006J04Rik; 4930479L12Rik
Summary
Predicted to be located in cytoplasm. Orthologous to human LRP2BP (LRP2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.2) and mammary gland adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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Location:
8 B1.1; 8 25.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46463639..46482515)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46010580..46029478)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:47020100-47020401 Neighboring gene coiled-coil domain containing 110 Neighboring gene cilia and flagella associated protein 96 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47060555-47060664 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene UFM1-specific peptidase 2 Neighboring gene ankyrin repeat domain 37 Neighboring gene sorting nexin 25 Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634 Neighboring gene cilia and flagella associated protein 97

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. Petersen HH, et al. J Cell Sci, 2003 Feb 1. PMID 12508107
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
LRP2-binding protein
Names
megalin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026278.3 → NP_080554.1  LRP2-binding protein

    See identical proteins and their annotated locations for NP_080554.1

    Status: VALIDATED

    Source sequence(s)
    AC114558, BB075157, BC051150
    Consensus CDS
    CCDS22286.1
    UniProtKB/Swiss-Prot
    Q3UV46, Q8CF18, Q8K0N7, Q9D4C6
    UniProtKB/TrEMBL
    G5E8E5
    Related
    ENSMUSP00000106010.3, ENSMUST00000110381.9
    Conserved Domains (3) summary
    smart00671
    Location:207 → 241
    SEL1; Sel1-like repeats
    COG0790
    Location:58 → 254
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:108 → 144
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46463639..46482515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509483.1 → XP_006509546.1  LRP2-binding protein isoform X1

    Conserved Domains (3) summary
    smart00671
    Location:181 → 215
    SEL1; Sel1-like repeats
    COG0790
    Location:18 → 139
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:36 → 69
    SLR; SLR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4C6.1 GenPept UniProtKB/Swiss-Prot:Q9D4C6

Gene LinkOut

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