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Nob1 NIN1/RPN12 binding protein 1 homolog [ Mus musculus (house mouse) ]

Gene ID: 67619, updated on 5-Mar-2024

Summary

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Official Symbol
Nob1provided by MGI
Official Full Name
NIN1/RPN12 binding protein 1 homologprovided by MGI
Primary source
MGI:MGI:1914869
See related
Ensembl:ENSMUSG00000003848 AllianceGenome:MGI:1914869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ART-4; Nob1p; Psmd8bp1; 1700021I09Rik
Summary
Predicted to enable endoribonuclease activity. Acts upstream of or within visual perception. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of preribosome, small subunit precursor. Is expressed in nervous system and neural retina. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 29.2), limb E14.5 (RPKM 26.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 54.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108139121..108151670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107412489..107425038, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 5 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene STARR-seq mESC enhancer starr_22606 Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene predicted gene, 39241 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nob1p is required for cleavage of the 3' end of 18S rRNA. Fatica A, et al. Mol Cell Biol, 2003 Mar. PMID 12588997, Free PMC Article
  2. Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse. Lei B. PLoS One, 2012. PMID 22937111, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118441, MGC144649, MGC144650

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within maturation of SSU-rRNA ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within ribosomal small subunit biogenesis ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleolus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein NOB1
Names
PSMD8 binding protein 1
nin one binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026277.3 → NP_080553.1  RNA-binding protein NOB1

    See identical proteins and their annotated locations for NP_080553.1

    Status: VALIDATED

    Source sequence(s)
    AC158364
    Consensus CDS
    CCDS22649.1
    UniProtKB/Swiss-Prot
    Q7TPR3, Q8BW10, Q9CRD7
    UniProtKB/TrEMBL
    Q148S3
    Related
    ENSMUSP00000003946.9, ENSMUST00000003946.9
    Conserved Domains (4) summary
    cd09876
    Location:7 → 115
    PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
    COG1439
    Location:8 → 292
    Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
    pfam15017
    Location:135 → 211
    AF1Q; Drug resistance and apoptosis regulator
    pfam08772
    Location:251 → 323
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    108139121..108151670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW10.1 GenPept UniProtKB/Swiss-Prot:Q8BW10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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