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Akt1s1 AKT1 substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 67605, updated on 21-Apr-2024

Summary

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Official Symbol
Akt1s1provided by MGI
Official Full Name
AKT1 substrate 1provided by MGI
Primary source
MGI:MGI:1914855
See related
Ensembl:ENSMUSG00000011096 AllianceGenome:MGI:1914855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lobe; Lobel; PRAS40; 1110012J22Rik
Summary
Involved in regulation of neuron apoptotic process. Located in cytosol. Is expressed in brain. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 52.6), ovary adult (RPKM 41.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7; 7 B3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44498648..44504845)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44849224..44855421)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling. Yang W, et al. CNS Neurosci Ther, 2017 May. PMID 28294542, Free PMC Article
  2. Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. Malla R, et al. Biochem Pharmacol, 2015 Jul 1. PMID 25931147
  3. PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. Völkers M, et al. EMBO Mol Med, 2014 Jan. PMID 24408966, Free PMC Article
  4. Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Völkers M, et al. Proc Natl Acad Sci U S A, 2013 Jul 30. PMID 23842089, Free PMC Article
  5. PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts. Kazi AA, et al. Mol Med, 2010 Sep-Oct. PMID 20464060, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
    Title: Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
  2. This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation.
    Title: PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.
  3. Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development
    Title: Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
  4. PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease.
    Title: PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
  5. PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR
    Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
  6. PRAS40 treatment improves hepatic insulin sensitivity and reduces systemic hyperglycaemia in obese mice.
    Title: PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
  7. PRAS40 phosphorylation acts as a molecular switch allowing mTORC1 activation during physiological growth, opening up unique possibilities for therapeutic regulation of the mTORC1 complex to mitigate pathologic myocardial hypertrophy by PRAS40
    Title: Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
  8. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
    Title: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
  9. These results suggest that a reduction in PRAS40 specifically impairs myoblast protein synthesis, cell cycle, proliferation and differentiation to myotubes.
    Title: PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts.
  10. after mTORC1 kinase activation by upstream regulators, PRAS40 is phosphorylated directly by mTOR, thus contributing to the relief of PRAS40-mediated substrate competition.
    Title: Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proline-rich AKT1 substrate 1
Names
AKT1 substrate 1 (proline-rich)
proline-rich AKT substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253920.1 → NP_001240849.1  proline-rich AKT1 substrate 1 isoform b

    See identical proteins and their annotated locations for NP_001240849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    AK141771, BE847693, BY100800
    Consensus CDS
    CCDS21218.1
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000103512.2, ENSMUST00000107880.9
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  2. NM_001290694.1 → NP_001277623.1  proline-rich AKT1 substrate 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (a)
    Source sequence(s)
    AA015487, AK141771, BB618044, BE847693
    Consensus CDS
    CCDS71954.1
    UniProtKB/TrEMBL
    E9QKI5, F6R8S6
    Related
    ENSMUSP00000103514.2, ENSMUST00000107882.8
    Conserved Domains (1) summary
    pfam15798
    Location:154 → 278
    PRAS; Proline-rich AKT1 substrate 1

  3. NM_001290695.1 → NP_001277624.1  proline-rich AKT1 substrate 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate first exon compared to variant 3. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA231178, AK141771, BE847693, W71279
    UniProtKB/Swiss-Prot
    Q9D1F4
    Conserved Domains (1) summary
    pfam15798
    Location:27 → 151
    PRAS; Proline-rich AKT1 substrate 1

  4. NM_001382480.1 → NP_001369409.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  5. NM_001382481.1 → NP_001369410.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  6. NM_001382482.1 → NP_001369411.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  7. NM_001382483.1 → NP_001369412.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  8. NM_001382484.1 → NP_001369413.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  9. NM_026270.4 → NP_080546.1  proline-rich AKT1 substrate 1 isoform b

    See identical proteins and their annotated locations for NP_080546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    AK141771, BE847693, BY103589
    Consensus CDS
    CCDS21218.1
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000049764.9, ENSMUST00000054343.15
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44498648..44504845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242937.2 → XP_030098797.1  proline-rich AKT1 substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000116149.3, ENSMUST00000127783.2
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1

  2. XM_006541117.3 → XP_006541180.1  proline-rich AKT1 substrate 1 isoform X1

    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:135 → 259
    PRAS; Proline-rich AKT1 substrate 1

  3. XM_006541118.5 → XP_006541181.1  proline-rich AKT1 substrate 1 isoform X3

    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:131 → 255
    PRAS; Proline-rich AKT1 substrate 1

  4. XM_036153382.1 → XP_036009275.1  proline-rich AKT1 substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128 → 252
    PRAS; Proline-rich AKT1 substrate 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1F4.1 GenPept UniProtKB/Swiss-Prot:Q9D1F4

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