U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Necap1 NECAP endocytosis associated 1 [ Mus musculus (house mouse) ]

Gene ID: 67602, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Necap1provided by MGI
Official Full Name
NECAP endocytosis associated 1provided by MGI
Primary source
MGI:MGI:1914852
See related
Ensembl:ENSMUSG00000030327 AllianceGenome:MGI:1914852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200016B17Rik
Summary
Involved in endocytosis. Located in clathrin-coated pit. Part of clathrin vesicle coat. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 44.7), CNS E18 (RPKM 35.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Necap1 in Genome Data Viewer
Location:
6 F2; 6 57.96 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122851516..122865902)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122874557..122888943)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box J2 Neighboring gene microRNA 7231 Neighboring gene STARR-seq mESC enhancer starr_17260 Neighboring gene complement component 3a receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2206 Neighboring gene STARR-positive B cell enhancer ABC_E687 Neighboring gene predicted gene 5316 Neighboring gene C-type lectin domain family 4, member a1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. Ritter B, et al. EMBO J, 2004 Oct 1. PMID 15359277, Free PMC Article
  2. NECAP1 loss of function leads to a severe infantile epileptic encephalopathy. Alazami AM, et al. J Med Genet, 2014 Apr. PMID 24399846
  3. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, et al. PLoS Biol, 2013 Oct. PMID 24130457, Free PMC Article
  4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. Ritter B, et al. EMBO Rep, 2003 Nov. PMID 14555962, Free PMC Article
  5. Definition of the consensus motif recognized by gamma-adaptin ear domains. Mattera R, et al. J Biol Chem, 2004 Feb 27. PMID 14665628

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NECAP1 mutation links trafficking pathway in early infantile epileptic encephalopathy.
    Title: NECAP1 loss of function leads to a severe infantile epileptic encephalopathy.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ00061

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adaptin ear-binding coat-associated protein 1
Names
NECAP endocytosis-associated protein 1
brain enriched NECAP2 similar protein
clathrin-coated vesicle coat protein
snoRNA MBI-129

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026267.3 → NP_080543.2  adaptin ear-binding coat-associated protein 1

    See identical proteins and their annotated locations for NP_080543.2

    Status: VALIDATED

    Source sequence(s)
    AK004805, AW046891
    Consensus CDS
    CCDS20505.1
    UniProtKB/Swiss-Prot
    Q3TH13, Q78JW3, Q8C4P1, Q9CR95
    UniProtKB/TrEMBL
    Q0VB06, Q571F3
    Related
    ENSMUSP00000032477.5, ENSMUST00000032477.6
    Conserved Domains (2) summary
    pfam07933
    Location:7 → 164
    DUF1681; Protein of unknown function (DUF1681)
    cl26247
    Location:161 → 275
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RNA

  1. NR_156733.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123874

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122851516..122865902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR95.2 GenPept UniProtKB/Swiss-Prot:Q9CR95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous