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Tespa1 thymocyte expressed, positive selection associated 1 [ Mus musculus (house mouse) ]

Gene ID: 67596, updated on 24-Apr-2024

Summary

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Official Symbol
Tespa1provided by MGI
Official Full Name
thymocyte expressed, positive selection associated 1provided by MGI
Primary source
MGI:MGI:1914846
See related
Ensembl:ENSMUSG00000034833 AllianceGenome:MGI:1914846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Itprid3; 5830405N20Rik; A430001F24Rik
Summary
Enables phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.0), spleen adult (RPKM 3.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 77.85 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (130158696..130199338)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (130322826..130363469)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily K member 7 Neighboring gene STARR-seq mESC enhancer starr_28331 Neighboring gene STARR-positive B cell enhancer ABC_E9814 Neighboring gene neurogenic differentiation 4 Neighboring gene STARR-seq mESC enhancer starr_28332 Neighboring gene STARR-positive B cell enhancer mm9_chr10:129735744-129736044 Neighboring gene STARR-positive B cell enhancer ABC_E8379 Neighboring gene STARR-positive B cell enhancer ABC_E11762 Neighboring gene STARR-positive B cell enhancer mm9_chr10:129774366-129774667 Neighboring gene STARR-positive B cell enhancer mm9_chr10:129800808-129801109 Neighboring gene STARR-seq mESC enhancer starr_28333 Neighboring gene vomeronasal 2, receptor 84 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway. Yang R, et al. J Transl Med, 2020 Nov 23. PMID 33228696, Free PMC Article
  2. Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice. Yao Y, et al. Front Immunol, 2018. PMID 29867947, Free PMC Article
  3. Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation. Lu Y, et al. Leukemia, 2023 May. PMID 36997676, Free PMC Article
  4. Thymic-specific regulation of TCR signaling by Tespa1. Lyu J, et al. Cell Mol Immunol, 2019 Dec. PMID 31316154, Free PMC Article
  5. Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. Wang D, et al. J Exp Med, 2014 Dec 15. PMID 25422497, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.
    Title: Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.
  2. Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
    Title: Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
  3. Thymic-specific regulation of TCR signaling by Tespa1.
    Title: Thymic-specific regulation of TCR signaling by Tespa1.
  4. Our study demonstrates that Tespa1 is essential for T cell-dependent B cell responses, and suggests an important role for Tespa1 during the development of autoimmune arthritis.
    Title: Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice.
  5. Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1
    Title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
  6. Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI.
    Title: Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
  7. Tespa1 is post-translationally modified upon intracellular Ca2+ increase in thymocytes.
    Title: Tespa1 protein is phosphorylated in response to store-operated calcium entry.
  8. Tespa1 is a component of the TCR signalosome and is essential for T-cell selection and maturation through regulation of TCR signaling during T-cell development.
    Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within TCR signalosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
part_of TCR signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TCR signalosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of TCR signalosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein TESPA1
Names
thymocyte-expressed positive selection-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429520.1 → NP_001416449.1  protein TESPA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  2. NM_001429521.1 → NP_001416450.1  protein TESPA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  3. NM_001429522.1 → NP_001416451.1  protein TESPA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  4. NM_001429523.1 → NP_001416452.1  protein TESPA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  5. NM_001429524.1 → NP_001416453.1  protein TESPA1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC159473

  6. NM_001429525.1 → NP_001416454.1  protein TESPA1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  7. NM_001429526.1 → NP_001416455.1  protein TESPA1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  8. NM_001429527.1 → NP_001416456.1  protein TESPA1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473

  9. NM_183264.5 → NP_899087.2  protein TESPA1 isoform a

    See identical proteins and their annotated locations for NP_899087.2

    Status: VALIDATED

    Source sequence(s)
    AC152977, AC159473
    Consensus CDS
    CCDS48735.1
    UniProtKB/Swiss-Prot
    Q3TR68, Q3U132, Q8CEN9
    Related
    ENSMUSP00000047284.9, ENSMUST00000042586.10
    Conserved Domains (1) summary
    pfam14722
    Location:130 → 251
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    130158696..130199338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514006.4 → XP_006514069.1  protein TESPA1 isoform X1

    See identical proteins and their annotated locations for XP_006514069.1

    UniProtKB/Swiss-Prot
    Q3TR68, Q3U132, Q8CEN9
    Conserved Domains (1) summary
    pfam14722
    Location:130 → 251
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U132.1 GenPept UniProtKB/Swiss-Prot:Q3U132

Gene LinkOut

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