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Ubxn11 UBX domain protein 11 [ Mus musculus (house mouse) ]

Gene ID: 67586, updated on 5-Mar-2024

Summary

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Official Symbol
Ubxn11provided by MGI
Official Full Name
UBX domain protein 11provided by MGI
Primary source
MGI:MGI:1914836
See related
Ensembl:ENSMUSG00000012126 AllianceGenome:MGI:1914836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Soc; Soci; Ubxd5; D4Bwg1540e; 4930506L07Rik
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human UBXN11 (UBX domain protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 53.9), thymus adult (RPKM 6.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133829811..133854095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134102500..134126784)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1658 Neighboring gene STARR-positive B cell enhancer ABC_E9600 Neighboring gene STARR-positive B cell enhancer ABC_E842 Neighboring gene STARR-positive B cell enhancer ABC_E4678 Neighboring gene STARR-positive B cell enhancer ABC_E10264 Neighboring gene CD52 antigen Neighboring gene STARR-seq mESC enhancer starr_11667 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133677585-133677803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133680177-133680360 Neighboring gene SH3 domain binding glutamic acid-rich protein-like 3 Neighboring gene centrosomal protein 85 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh H, et al. Mol Cell Biol, 2002 May. PMID 11940653, Free PMC Article
  2. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. Aksu S, et al. J Appl Genet, 2007. PMID 17495347
  3. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 11
Names
UBX domain containing 5
UBX domain-containing protein 5
socius

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026257.3 → NP_080533.1  UBX domain-containing protein 11

    See identical proteins and their annotated locations for NP_080533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AK048494, AL670680
    Consensus CDS
    CCDS18763.1
    UniProtKB/Swiss-Prot
    Q8C843, Q8VCP5, Q9CWP0, Q9D572
    Related
    ENSMUSP00000074255.5, ENSMUST00000074690.11
    Conserved Domains (3) summary
    pfam08059
    Location:232 → 302
    SEP; SEP domain
    cl00155
    Location:394 → 461
    UBQ; Ubiquitin-like proteins
    cl21454
    Location:172 → 225
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_045571.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is thought not to be protein-coding.
    Source sequence(s)
    AK048494, AL670680
    Related
    ENSMUST00000156323.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133829811..133854095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539124.4 → XP_006539187.1  UBX domain-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    I7HIQ5
    Related
    ENSMUSP00000064030.3, ENSMUST00000070246.9
    Conserved Domains (2) summary
    cd17077
    Location:314 → 383
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:153 → 224
    SEP; SEP domain

  2. XM_006539127.4 → XP_006539190.1  UBX domain-containing protein 11 isoform X5

    Conserved Domains (1) summary
    cl02662
    Location:271 → 294
    SEP; SEP domain

  3. XM_006539122.3 → XP_006539185.1  UBX domain-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_006539185.1

    Conserved Domains (2) summary
    cd17077
    Location:320 → 389
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:159 → 230
    SEP; SEP domain

  4. XM_030253726.2 → XP_030109586.1  UBX domain-containing protein 11 isoform X4

    UniProtKB/TrEMBL
    I7HIQ5
    Conserved Domains (2) summary
    cd17077
    Location:237 → 306
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:76 → 147
    SEP; SEP domain

  5. XM_006539123.4 → XP_006539186.1  UBX domain-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_006539186.1

    Conserved Domains (2) summary
    cd17077
    Location:320 → 389
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:159 → 230
    SEP; SEP domain

  6. XM_011250325.4 → XP_011248627.1  UBX domain-containing protein 11 isoform X1

    Conserved Domains (2) summary
    cd17077
    Location:363 → 432
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:202 → 273
    SEP; SEP domain

  7. XM_011250326.4 → XP_011248628.1  UBX domain-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_011248628.1

    Conserved Domains (2) summary
    cd17077
    Location:320 → 389
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:159 → 230
    SEP; SEP domain

RNA

  1. XR_390778.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D572.1 GenPept UniProtKB/Swiss-Prot:Q9D572

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