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Loxl4 lysyl oxidase-like 4 [ Mus musculus (house mouse) ]

Gene ID: 67573, updated on 5-Mar-2024

Summary

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Official Symbol
Loxl4provided by MGI
Official Full Name
lysyl oxidase-like 4provided by MGI
Primary source
MGI:MGI:1914823
See related
Ensembl:ENSMUSG00000025185 AllianceGenome:MGI:1914823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Loxc; 4833426I20Rik
Summary
Enables protein-lysine 6-oxidase activity. Predicted to be involved in collagen fibril organization and peptidyl-lysine oxidation. Located in extracellular region. Is expressed in several structures, including gut; male reproductive gland or organ; otic capsule; skeleton; and trachea. Orthologous to human LOXL4 (lysyl oxidase like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 3.3), bladder adult (RPKM 3.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Loxl4 in Genome Data Viewer
Location:
19 C3; 19 36.56 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42580718..42601326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42592279..42612806, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7660 Neighboring gene predicted gene, 41851 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene STARR-seq mESC enhancer starr_46188 Neighboring gene predicted gene, 25216 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 2 Neighboring gene predicted gene, 19437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer. Choi SK, et al. Oncotarget, 2017 Feb 14. PMID 28060764, Free PMC Article
  2. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. Li H, et al. Genes (Basel), 2021 Mar 31. PMID 33807332, Free PMC Article
  3. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. Ito H, et al. J Biol Chem, 2001 Jun 29. PMID 11292829
  4. Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Pischon N, et al. Calcif Tissue Int, 2009 Aug. PMID 19458888, Free PMC Article
  5. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. Goodwin AF, et al. J Dent Res, 2020 Nov. PMID 32623954, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
    Title: LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
  2. These results demonstrate that weak LOXL4 expression leads to remodeling of the extracellular matrix through induction of collagen synthesis, deposition, and structural changes.
    Title: LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine 6-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine 6-oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine 6-oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
lysyl oxidase homolog 4
Names
lysyl oxidase-like protein 4
lysyl oxidase-related protein C
NP_001157783.1
NP_444313.3
XP_036017562.1
XP_036017563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164311.1 → NP_001157783.1  lysyl oxidase homolog 4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124552, AK014331, BC053925, BY145829
    Consensus CDS
    CCDS50441.1
    UniProtKB/TrEMBL
    E9Q600, Q6NV59
    Related
    ENSMUSP00000125803.2, ENSMUST00000164786.8
    Conserved Domains (3) summary
    smart00202
    Location:33 → 133
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:42 → 133
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01186
    Location:535 → 730
    Lysyl_oxidase; Lysyl oxidase

  2. NM_053083.3 → NP_444313.3  lysyl oxidase homolog 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_444313.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC124552, AK014331, BC053925, BY145829
    Consensus CDS
    CCDS29830.1
    UniProtKB/Swiss-Prot
    E9PXI3, Q924C6
    UniProtKB/TrEMBL
    Q6NV59
    Related
    ENSMUSP00000026190.8, ENSMUST00000026190.14
    Conserved Domains (3) summary
    smart00202
    Location:33 → 133
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:42 → 133
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01186
    Location:534 → 729
    Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42580718..42601326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161669.1 → XP_036017562.1  lysyl oxidase homolog 4 isoform X1

    UniProtKB/TrEMBL
    Q6NV59
    Conserved Domains (2) summary
    smart00202
    Location:46 → 146
    SR; Scavenger receptor Cys-rich
    pfam01186
    Location:549 → 747
    Lysyl_oxidase; Lysyl oxidase

  2. XM_036161670.1 → XP_036017563.1  lysyl oxidase homolog 4 isoform X2

    UniProtKB/TrEMBL
    Q6NV59
    Conserved Domains (2) summary
    smart00202
    Location:46 → 146
    SR; Scavenger receptor Cys-rich
    pfam01186
    Location:548 → 746
    Lysyl_oxidase; Lysyl oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924C6.2 GenPept UniProtKB/Swiss-Prot:Q924C6

Gene LinkOut

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