Gpr89 G protein-coupled receptor 89 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr89provided by MGI
Official Full Name: G protein-coupled receptor 89provided by MGI
Primary source: MGI:MGI:1914799
See related: Ensembl:ENSMUSG00000028096 AllianceGenome:MGI:1914799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SH120; Gpr89a; 4933412D19Rik
Summary: Predicted to enable voltage-gated anion channel activity. Involved in T cell differentiation. Acts upstream of or within skin development. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in Golgi cisterna membrane. Is expressed in several structures, including alimentary system; clavicle; ganglia; liver lobe; and ventral grey horn. Orthologous to several human genes including GPR89A (G protein-coupled receptor 89A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 62.2), large intestine adult (RPKM 23.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 42.01 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96775630..96812662, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96868298..96905346, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that GPHR-dependent Golgi luminal acidification plays an essential role in the structural and functional maintenance of purkinje cells and basket cells.
Title: Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125331 (e-PCR)
- UniSTS:162153

AI132457 (e-PCR)
- UniSTS:207538

AI314638 (e-PCR)
- UniSTS:159157

AU022450 (e-PCR)
- UniSTS:167363

Pdzk1 (e-PCR), detects polymorphism
- UniSTS:526833

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular pH reduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi pH regulator

Names: protein GPR89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418418.1 → NP_001405347.1 Golgi pH regulator isoform 2

Status: VALIDATED

Source sequence(s)

AC127297
NM_026229.5 → NP_080505.1 Golgi pH regulator isoform 1

See identical proteins and their annotated locations for NP_080505.1

Status: VALIDATED

Source sequence(s)

AC127297

Consensus CDS

CCDS17650.1

UniProtKB/Swiss-Prot

Q8BS95, Q9D455

Related

ENSMUSP00000029738.8, ENSMUST00000029738.14

Conserved Domains (2) summary

pfam12430
Location:276 → 446

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:140 → 207

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal