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Fam120b family with sequence similarity 120, member B [ Mus musculus (house mouse) ]

Gene ID: 67544, updated on 21-Apr-2024

Summary

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Official Symbol
Fam120bprovided by MGI
Official Full Name
family with sequence similarity 120, member Bprovided by MGI
Primary source
MGI:MGI:1914794
See related
Ensembl:ENSMUSG00000014763 AllianceGenome:MGI:1914794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCPG; Pgcc1; mKIAA1838; 4932442K08Rik
Summary
Acts upstream of or within fat cell differentiation and peroxisome proliferator activated receptor signaling pathway. Located in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human FAM120B (family with sequence similarity 120B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 6.5), CNS E18 (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A2; 17 8.95 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15616464..15653843)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15396202..15433581)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10510 Neighboring gene RIKEN cDNA A930024N18 gene Neighboring gene delta like canonical Notch ligand 1 Neighboring gene STARR-positive B cell enhancer ABC_E1931 Neighboring gene predicted gene, 49668 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene STARR-positive B cell enhancer ABC_E5573 Neighboring gene TATA box binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia. Liu Z, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Nov 1. PMID 34339838, Free PMC Article
  2. Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy. Keil S, et al. ChemMedChem, 2011 Apr 4. PMID 21400663
  3. A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. Andrews AM, et al. Nat Commun, 2018 Jul 3. PMID 29968717, Free PMC Article
  4. Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse. Trachtulec Z, et al. Genetics, 2008 Mar. PMID 18245833, Free PMC Article
  5. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Li D, et al. Mol Endocrinol, 2007 Oct. PMID 17595322

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
    Title: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
  2. Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity.
    Title: A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.
  3. Sulfonylthiadiazoles with an unusual binding mode were shown as partial dual peroxisome proliferator-activated receptor (PPAR) gamma/delta agonists with high potency and in vivo efficacy.
    Title: Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.
  4. CCPG is a bona fide coactivator and promotes adipogenesis in a PPARgamma-dependent manner.
    Title: Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1838, MGC109687

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
constitutive coactivator of peroxisome proliferator-activated receptor gamma
Names
constitutive coactivator of PPAR-gamma
constitutive coactivator of PPARG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357822.1 → NP_001344751.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma

    Status: VALIDATED

    Source sequence(s)
    AC154378, BC085163
    Consensus CDS
    CCDS37453.1
    UniProtKB/Swiss-Prot
    Q5DTU5, Q6RI63, Q8BK59, Q8BVH5, Q8BWQ3, Q8C158, Q99LL4, Q9DAC3

  2. NM_024203.3 → NP_077165.2  constitutive coactivator of peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_077165.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a 786aa protein.
    Source sequence(s)
    AK132211, BC085163, BY073650
    Consensus CDS
    CCDS37453.1
    UniProtKB/Swiss-Prot
    Q5DTU5, Q6RI63, Q8BK59, Q8BVH5, Q8BWQ3, Q8C158, Q99LL4, Q9DAC3
    Related
    ENSMUSP00000054420.7, ENSMUST00000055352.8

RNA

  1. NR_033586.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' CDS, which includes an in-frame stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate.
    Source sequence(s)
    BC066088, BC085163, CB518733
    Related
    ENSMUST00000231274.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15616464..15653843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RI63.1 GenPept UniProtKB/Swiss-Prot:Q6RI63

Gene LinkOut

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