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Fgfr1op2 FGFR1 oncogene partner 2 [ Mus musculus (house mouse) ]

Gene ID: 67529, updated on 5-Mar-2024

Summary

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Official Symbol
Fgfr1op2provided by MGI
Official Full Name
FGFR1 oncogene partner 2provided by MGI
Primary source
MGI:MGI:1914779
See related
Ensembl:ENSMUSG00000040242 AllianceGenome:MGI:1914779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500031J01Rik
Summary
Enables identical protein binding activity. Acts upstream of or within wound healing. Predicted to be located in cytoplasm. Is expressed in thymus primordium. Orthologous to human FGFR1OP2 (FGFR1 oncogene partner 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 25.4), testis adult (RPKM 22.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146479401..146500696)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146577903..146599198)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146470563-146470746 Neighboring gene STARR-positive B cell enhancer ABC_E10421 Neighboring gene integrator complex subunit 13 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1076 Neighboring gene mediator complex subunit 21 Neighboring gene predicted pseudogene 6654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model. Qin H, et al. Haematologica, 2016 Mar. PMID 26589915, Free PMC Article
  2. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, et al. Am J Pathol, 2010 Jan. PMID 19959814, Free PMC Article
  3. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. Patra D, et al. PLoS One, 2014. PMID 25147951, Free PMC Article
  4. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGFR1OP2-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia and T-cell lymphoma in a mouse model.
    Title: FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model.
  2. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure.
    Title: Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to wounding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FGFR1 oncogene partner 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347513.1 → NP_001334442.1  FGFR1 oncogene partner 2 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK151318, AK169380, BF466380
    Consensus CDS
    CCDS85186.1
    UniProtKB/Swiss-Prot
    Q9CRA9
    Related
    ENSMUSP00000098352.4, ENSMUST00000067404.13
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 183
    SIKE; SIKE family

  2. NM_026218.2 → NP_080494.1  FGFR1 oncogene partner 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_080494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK004662, AK005320, AK050102, AK159805
    Consensus CDS
    CCDS39711.1
    UniProtKB/Swiss-Prot
    Q3TEX1, Q3TW81, Q9CRA9, Q9D7R0
    Related
    ENSMUSP00000107292.3, ENSMUST00000111663.9
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 221
    SIKE; SIKE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    146479401..146500696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRA9.1 GenPept UniProtKB/Swiss-Prot:Q9CRA9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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